OBJECTIVE: To report the temporal pattern of subclinical rhythmic electrographic discharge of adults (SREDA) and its response to lorazepam during EEG-video monitoring. METHODS: We recorded EEG-video for 3 days in a patient with SREDA, who was previously misdiagnosed with generalized epilepsy. Because SREDA had a very prominent signature on density spectral array (DSA), we used DSA to study the pattern of SREDA over the diurnal cycle, and the response to intravenous lorazepam. RESULTS: SREDA occurred in both waking and sleep, but tended to occur in single bursts in waking and in longer clusters during sleep. Lorazepam suppressed SREDA. CONCLUSIONS: The temporal pattern of SREDA varies during the sleep-wake cycle. Lorazepam appears to suppress SREDA. SIGNIFICANCE: Response to lorazepam cannot distinguish SREDA from electrographic seizure activity.
OBJECTIVE: To report the temporal pattern of subclinical rhythmic electrographic discharge of adults (SREDA) and its response to lorazepam during EEG-video monitoring. METHODS: We recorded EEG-video for 3 days in a patient with SREDA, who was previously misdiagnosed with generalized epilepsy. Because SREDA had a very prominent signature on density spectral array (DSA), we used DSA to study the pattern of SREDA over the diurnal cycle, and the response to intravenous lorazepam. RESULTS: SREDA occurred in both waking and sleep, but tended to occur in single bursts in waking and in longer clusters during sleep. Lorazepam suppressed SREDA. CONCLUSIONS: The temporal pattern of SREDA varies during the sleep-wake cycle. Lorazepam appears to suppress SREDA. SIGNIFICANCE: Response to lorazepam cannot distinguish SREDA from electrographic seizure activity.