| Literature DB >> 22100754 |
Daniele Vergara1, Claudia Bellomo, Xingcai Zhang, Viviana Vergaro, Andrea Tinelli, Vito Lorusso, Ross Rinaldi, Yuri M Lvov, Stefano Leporatti, Michele Maffia.
Abstract
The sonication-assisted layer-by-layer (SLBL) technology was developed to combine necessary factors for an efficient drug-delivery system: (i) control of nanocolloid size within 100 - 300 nm, (ii) high drug content (70% wt), (iii) shell biocompatibility and biodegradability, (iv) sustained controlled release, and (v) multidrug-loaded system. Stable nanocolloids of Paclitaxel (PTX) and lapatinib were prepared by the SLBL method. In a multidrug-resistant (MDR) ovarian cancer cell line, OVCAR-3, lapatinib/PTX nanocolloids mediated an enhanced cell growth inhibition in comparison with the PTX-only treatment. A series of in vitro cell assays were used to test the efficacy of these formulations. The small size and functional versatility of these nanoparticles, combined with their ability to incorporate various drugs, indicates that lapatinib/PTX nanocolloids may have in vivo therapeutic applications.Entities:
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Year: 2011 PMID： 22100754 DOI： 10.1016/j.nano.2011.10.014
Source DB: PubMed Journal: Nanomedicine ISSN： 1549-9634 Impact factor: 5.307