| Literature DB >> 22100174 |
Wei Zhou1, Li Wang, Shan-Miao Gou, Tong-Ling Wang, Meng Zhang, Tao Liu, Chun-You Wang.
Abstract
Glycogen synthase kinase-3 beta (GSK-3β), a serine/threonine protein kinase, plays a vital role in the tumorigenesis of many cancers, but its role in pancreatic cancer remains unknown. In this study, we showed that GSK-3β was aberrantly activated in pancreatic cancer. GSK-3β knockdown resulted in arrested proliferation and increased apoptosis in pancreatic cancer cell lines. Expression of Bcl-2 and vascular endothelial growth factor (VEGF) decreased significantly in a GSK-3β knockdown group. In a xenograft tumor model, GSK-3β knockdown inhibited tumor growth and angiogenesis. Our study showed that GSK-3β may become a promising therapeutic target for human pancreatic cancer.Entities:
Mesh：
Substances：
Year: 2011 PMID： 22100174 DOI： 10.1016/j.canlet.2011.10.033
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679