Literature DB >> 22100139

Synthesis, antiproliferative activities and telomerase inhibition evaluation of novel asymmetrical 1,2-disubstituted amidoanthraquinone derivatives.

Chia-Chung Lee1, Kuo-Feng Huang, Pen-Yuan Lin, Fong-Chun Huang, Chun-Liang Chen, Tsung-Chih Chen, Jih-Hwa Guh, Jing-Jer Lin, Hsu-Shan Huang.   

Abstract

A series of diversely asymmetrical mono- or disubstituted 1,2-diamidoanthraquinone derivatives were synthesized and evaluated for drug-induced cytotoxicity by SRB assay, telomerase inhibitory activity by TRAP assay, and hTERT expression by SEAP assay. Interestingly, compounds 4, 11, 21, 32 and 36 exhibited selective potent antiproliferative activities by NCI with IC(50) values in the micromolar range. Of these, only compound 8 showed an IC(50) value of 0.95 μM against PC-3 cell lines (human prostate cancer) by SRB assay. All the synthesized compounds exhibited a poor or modest telomerase inhibitory activity by TRAP assay suggesting another mode of action for these compounds. Compound 11 showed broad inhibition against different types of cancer cell lines in the micromolar and submicromolar range. Crown
Copyright © 2011. Published by Elsevier Masson SAS. All rights reserved.

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Year:  2011        PMID： 22100139     DOI： 10.1016/j.ejmech.2011.10.059

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  5 in total

Review 1.  Causes of genome instability: the effect of low dose chemical exposures in modern society.

Authors:  Sabine A S Langie; Gudrun Koppen; Daniel Desaulniers; Fahd Al-Mulla; Rabeah Al-Temaimi; Amedeo Amedei; Amaya Azqueta; William H Bisson; Dustin G Brown; Gunnar Brunborg; Amelia K Charles; Tao Chen; Annamaria Colacci; Firouz Darroudi; Stefano Forte; Laetitia Gonzalez; Roslida A Hamid; Lisbeth E Knudsen; Luc Leyns; Adela Lopez de Cerain Salsamendi; Lorenzo Memeo; Chiara Mondello; Carmel Mothersill; Ann-Karin Olsen; Sofia Pavanello; Jayadev Raju; Emilio Rojas; Rabindra Roy; Elizabeth P Ryan; Patricia Ostrosky-Wegman; Hosni K Salem; A Ivana Scovassi; Neetu Singh; Monica Vaccari; Frederik J Van Schooten; Mahara Valverde; Jordan Woodrick; Luoping Zhang; Nik van Larebeke; Micheline Kirsch-Volders; Andrew R Collins
Journal:  Carcinogenesis       Date:  2015-06       Impact factor: 4.944

2.  A unique amidoanthraquinone derivative displays antiproliferative activity against human hormone-refractory metastatic prostate cancers through activation of LKB1-AMPK-mTOR signaling pathway.

Authors:  Jui-Ling Hsu; Shih-Ping Liu; Chia-Chung Lee; Lih-Ching Hsu; Yunn-Fang Ho; Hsu-Shan Huang; Jih-Hwa Guh
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2014-07-09       Impact factor: 3.000

3.  Design, Synthesis and Molecular Docking Analysis of Flavonoid Derivatives as Potential Telomerase Inhibitors.

Authors:  Zhan-Fang Fan; Sai-Tim Ho; Rui Wen; Ya Fu; Lei Zhang; Jian Wang; Chun Hu; Pang-Chui Shaw; Yang Liu; Mao-Sheng Cheng
Journal:  Molecules       Date:  2019-09-01       Impact factor: 4.411

4.  New approaches of PARP-1 inhibitors in human lung cancer cells and cancer stem-like cells by some selected anthraquinone-derived small molecules.

Authors:  Yu-Ru Lee; Dah-Shyong Yu; Ya-Chun Liang; Kuo-Feng Huang; Shih-Jie Chou; Tsung-Chih Chen; Chia-Chung Lee; Chun-Liang Chen; Shih-Hwa Chiou; Hsu-Shan Huang
Journal:  PLoS One       Date:  2013-02-25       Impact factor: 3.240

5.  Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation.

Authors:  Lien-Cheng Chang; Tsung-Chih Chen; Shiag-Jiun Chen; Chun-Liang Chen; Chia-Chung Lee; Shih-Hsiung Wu; Yun Yen; Hsu-Shan Huang; Jing-Jer Lin
Journal:  Oncotarget       Date:  2016-10-18
  5 in total

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