Literature DB >> 22099161

Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders.

Joseph Lemire1, Vasu D Appanna.   

Abstract

Aluminum (Al) has been implicated in a variety of neurological diseases. However, the molecular mechanisms that enable Al to be involved in these disorders have yet to be fully delineated. Using astrocytes as a model of the cerebral cellular system, we have uncovered the biochemical networks that are affected by Al toxicity. In this review, we reveal how the inhibitory influence of Al on ATP production and on mitochondrial functions help generate globular astrocytes that are fat producing machines. These biological events may be the contributing factors to Al-triggered brain disorders.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 22099161     DOI： 10.1016/j.jinorgbio.2011.07.001

Source DB:  PubMed          Journal:  J Inorg Biochem        ISSN： 0162-0134            Impact factor:   4.155


  8 in total

Review 1.  Brain metabolism and Alzheimer's disease: the prospect of a metabolite-based therapy.

Authors:  S C Thomas; A Alhasawi; V P Appanna; C Auger; V D Appanna
Journal:  J Nutr Health Aging       Date:  2015-01       Impact factor: 4.075

Review 2.  Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts.

Authors:  Calvin C Willhite; Nataliya A Karyakina; Robert A Yokel; Nagarajkumar Yenugadhati; Thomas M Wisniewski; Ian M F Arnold; Franco Momoli; Daniel Krewski
Journal:  Crit Rev Toxicol       Date:  2014-10       Impact factor: 5.635

Review 3.  Krebs cycle: activators, inhibitors and their roles in the modulation of carcinogenesis.

Authors:  Amin Gasmi; Massimiliano Peana; Maria Arshad; Monica Butnariu; Alain Menzel; Geir Bjørklund
Journal:  Arch Toxicol       Date:  2021-03-02       Impact factor: 5.153

Review 4.  Dysfunctional mitochondrial bioenergetics and the pathogenesis of hepatic disorders.

Authors:  Christopher Auger; Azhar Alhasawi; Manuraj Contavadoo; Vasu D Appanna
Journal:  Front Cell Dev Biol       Date:  2015-06-25

Review 5.  Aluminum-induced entropy in biological systems: implications for neurological disease.

Authors:  Christopher A Shaw; Stephanie Seneff; Stephen D Kette; Lucija Tomljenovic; John W Oller; Robert M Davidson
Journal:  J Toxicol       Date:  2014-10-02

Review 6.  The putative role of environmental aluminium in the development of chronic neuropathology in adults and children. How strong is the evidence and what could be the mechanisms involved?

Authors:  Gerwyn Morris; Basant K Puri; Richard E Frye
Journal:  Metab Brain Dis       Date:  2017-07-27       Impact factor: 3.584

7.  Complete mitochondrial genome of the aluminum-tolerant fungus Rhodotorula taiwanensis RS1 and comparative analysis of Basidiomycota mitochondrial genomes.

Authors:  Xue Qiang Zhao; Tomoko Aizawa; Jessica Schneider; Chao Wang; Ren Fang Shen; Michio Sunairi
Journal:  Microbiologyopen       Date:  2013-02-21       Impact factor: 3.139

8.  Aluminum Exposure from Parenteral Nutrition: Early Bile Canaliculus Changes of the Hepatocyte.

Authors:  Amanda R Hall; Ha Le; Chris Arnold; Janet Brunton; Robert Bertolo; Grant G Miller; Gordon A Zello; Consolato Sergi
Journal:  Nutrients       Date:  2018-06-04       Impact factor: 5.717
  8 in total

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