Literature DB >> 2209712

A new H-oxime restores rat diaphragm contractility after esterase inhibition in vitro.

P Alberts1.   

Abstract

Acetylcholine esterase inhibitors block cholinergic neurotransmission. This blockade can be reversed by oximes. However, a universally effective esterase reactivator does not exist. A new H-oxime, HLö 7, was tested on rat diaphragm strips. Electrically evoked contractions were blocked by di-2-propyl fluorophosphate (DFP), tabun, sarin and soman. Whereas pralidoxime, obidoxime and HI 6 reversed the blockade induced by three of these organophosphorus compounds, HLö 7 restored the contractions after short blockade induced by all four organophosphorus compounds tested.

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Year:  1990        PMID： 2209712     DOI： 10.1016/0014-2999(90)90682-v

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  Synthesis and Molecular Properties of Nerve Agent Reactivator HLö-7 Dimethanesulfonate.

Authors:  Fu-Lian Hsu; Su Y Bae; Jack McGuire; Dana R Anderson; Stephanie M Bester; Jude J Height; Scott D Pegan; Andrew J Walz
Journal:  ACS Med Chem Lett       Date:  2019-03-28       Impact factor: 4.345

2.  Pharmacokinetics of the oximes HI 6 and HLö 7 in dogs after i.m. injection with newly developed dry/wet autoinjectors.

Authors:  U Spöhrer; H Thiermann; R Klimmek; P Eyer
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153

Review 3.  Unequal efficacy of pyridinium oximes in acute organophosphate poisoning.

Authors:  Biljana Antonijevic; Milos P Stojiljkovic
Journal:  Clin Med Res       Date:  2007-03

4.  HLö 7 dimethanesulfonate, a potent bispyridinium-dioxime against anticholinesterases.

Authors:  P Eyer; I Hagedorn; R Klimmek; P Lippstreu; M Löffler; H Oldiges; U Spöhrer; I Steidl; L Szinicz; F Worek
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153

5.  Efficacy of HLö-7 and pyrimidoxime as antidotes of nerve agent poisoning in mice.

Authors:  J G Clement; A S Hansen; C A Boulet
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153

6.  Treatment of tabun poisoned guinea-pigs with atropine, HLö 7 or HI 6: effect on respiratory and circulatory function.

Authors:  F Worek; T Kirchner; L Szinicz
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153
  6 in total

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