BACKGROUND: More than 60% of children with acute myeloid leukemia (AML) become long-term survivors, and approximately 50% are cured with chemotherapy only. Limited data exist about their long-term morbidity and social outcomes. The aim of the study was to compare the self-reported use of health care services, health experience, social outcomes, and lifestyle behavior of AML survivors with that of their sibling controls. METHODS: This population-based study included 138 children treated for AML according to the Nordic Society of Pediatric Hematology and Oncology (NOPHO)-AML-84, -88, and -93 trials, and alive by June 30, 2007. Patients treated with hematopoietic stem cell transplantation (HSCT) or relapse were not included. Altogether, 102 (74%) survivors and 91% of their siblings completed a questionnaire. RESULTS: The median follow-up was 11 (range 4-25) years after diagnosis. AML survivors had no increased rate of hospitalization compared with sibling controls, but were more often receiving prescription drugs, especially for asthma (23% vs. 9%, P = 0.03). Self-reported health experience was excellent or very good in 77% and comparable with that of siblings. Educational achievement, employment, and marital status were comparable in the two groups. Among surviving AML patients, 23% were current smokers and 24% of their siblings were current smokers. CONCLUSIONS: The self-reported health of children treated on NOPHO-AML protocols without HSCT was good, and their use of health care services was limited. Reported health and social outcomes were comparable to those of their siblings. Many survivors were smoking which may increase the risk of late effects.
BACKGROUND: More than 60% of children with acute myeloid leukemia (AML) become long-term survivors, and approximately 50% are cured with chemotherapy only. Limited data exist about their long-term morbidity and social outcomes. The aim of the study was to compare the self-reported use of health care services, health experience, social outcomes, and lifestyle behavior of AML survivors with that of their sibling controls. METHODS: This population-based study included 138 children treated for AML according to the Nordic Society of Pediatric Hematology and Oncology (NOPHO)-AML-84, -88, and -93 trials, and alive by June 30, 2007. Patients treated with hematopoietic stem cell transplantation (HSCT) or relapse were not included. Altogether, 102 (74%) survivors and 91% of their siblings completed a questionnaire. RESULTS: The median follow-up was 11 (range 4-25) years after diagnosis. AML survivors had no increased rate of hospitalization compared with sibling controls, but were more often receiving prescription drugs, especially for asthma (23% vs. 9%, P = 0.03). Self-reported health experience was excellent or very good in 77% and comparable with that of siblings. Educational achievement, employment, and marital status were comparable in the two groups. Among surviving AMLpatients, 23% were current smokers and 24% of their siblings were current smokers. CONCLUSIONS: The self-reported health of children treated on NOPHO-AML protocols without HSCT was good, and their use of health care services was limited. Reported health and social outcomes were comparable to those of their siblings. Many survivors were smoking which may increase the risk of late effects.
Authors: Tseng Tien Huang; Yan Chen; Andrew C Dietz; Yutaka Yasui; Sarah S Donaldson; Dennis C Stokes; Marilyn Stovall; Wendy M Leisenring; Charles A Sklar; Lisa R Diller; Ann C Mertens; Gregory T Armstrong; Daniel M Green; Leslie L Robison; Kirsten K Ness Journal: Pediatr Blood Cancer Date: 2013-10-11 Impact factor: 3.167
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Authors: Robert E Goldsby; Kayla L Stratton; Shannon Raber; Arthur Ablin; Louise C Strong; Kevin Oeffinger; Charles A Sklar; Gregory T Armstrong; Leslie L Robison; Smita Bhatia; Wendy M Leisenring Journal: Cancer Date: 2017-11-03 Impact factor: 6.860
Authors: Kristen J Stefanski; Julia S Anixt; Pamela Goodman; Katherine Bowers; Wendy Leisenring; K Scott Baker; Karen Burns; Rebecca Howell; Stella Davies; Leslie L Robison; Gregory T Armstrong; Kevin R Krull; Christopher Recklitis Journal: J Natl Cancer Inst Date: 2021-04-06 Impact factor: 13.506
Authors: James L Klosky; Carrie R Howell; Zhenghong Li; Rebecca H Foster; Ann C Mertens; Leslie L Robison; Kirsten K Ness Journal: J Pediatr Psychol Date: 2012-03-16
Authors: Mari Wilhelmsson; Heidi Glosli; Marianne Ifversen; Jonas Abrahamsson; Jacek Winiarski; Kirsi Jahnukainen; Henrik Hasle Journal: Bone Marrow Transplant Date: 2018-09-21 Impact factor: 5.483