Literature DB >> 22095927

Antidiabetic effect of the total polyphenolic acids fraction from Salvia miltiorrhiza Bunge in diabetic rats.

Mingqing Huang1, Youliang Xie, Lidian Chen, Kedan Chu, Shuisheng Wu, Jinjian Lu, Xiuping Chen, Yitao Wang, Xiaoping Lai.   

Abstract

An investigation was made to evaluate the therapeutic potential of the total polyphenolic acids fraction (PAF) from Salvia miltiorrhiza Bunge in the type 2 diabetes mellitus rats model with an oral dose of 187 mg/kg for 28 days. The results showed that PAF induced a significant decrease in fasting blood glucose (FBG), fasting blood insulin (FINS), total cholesterol (TC), triglyceride (TG) and blood urea nitrogen (BUN), and an obvious increase in insulin sensitivity index (ISI) in diabetic rats induced by a high fat diet and a low dose of streptozocin (STZ). These results suggested that PAF has antidiabetic potential in vivo.
Copyright © 2011 John Wiley & Sons, Ltd.

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Year:  2011        PMID： 22095927     DOI： 10.1002/ptr.3654

Source DB:  PubMed          Journal:  Phytother Res        ISSN： 0951-418X            Impact factor:   5.878


  8 in total

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Review 6.  Bioactive Components of Salvia and Their Potential Antidiabetic Properties: A Review.

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8.  Therapeutic Effects of Lithospermate B Complexed with Mg2+ or Zn2+ on Metabolic Syndrome Induced in Rats Fed with High-Fat Diet.

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