Literature DB >> 22095645

High-throughput screening for inhibitors of sialyl- and fucosyltransferases.

Cory D Rillahan1, Steven J Brown, Amy C Register, Hugh Rosen, James C Paulson.   

Abstract

Sweet screens: A high-throughput screening platform for identification of inhibitors of sialyl- and fucosyltransferases based on fluorescence polarization (FP) has been developed. An analogue of the natural donor substrate carrying a fluorescent label (green star) is transferred to a glycoprotein acceptor, which results in robust FP. The screening of 16,000 compounds against different glycosyltransferases has identified various interesting inhibitors.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2011        PMID： 22095645      PMCID： PMC3245354          DOI： 10.1002/anie.201105065

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  17 in total

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Authors:  Z Li; S Mehdi; I Patel; J Kawooya; M Judkins; W Zhang; K Diener; A Lozada; D Dunnington
Journal:  J Biomol Screen       Date:  2000-02

2.  Small molecule inhibitors of mucin-type O-linked glycosylation from a uridine-based library.

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3.  Identification of active-site inhibitors of MurG using a generalizable, high-throughput glycosyltransferase screen.

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4.  A highly sensitive fluorometric assay for sialyltransferase activity using CMP-9-fluoresceinyl-NeuAc as donor.

Authors:  H J Gross; U Sticher; R Brossmer
Journal:  Anal Biochem       Date:  1990-04       Impact factor: 3.365

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6.  The asparagine-linked oligosaccharides on bovine fetuin. Structural analysis of N-glycanase-released oligosaccharides by 500-megahertz 1H NMR spectroscopy.

Authors:  E D Green; G Adelt; J U Baenziger; S Wilson; H Van Halbeek
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Authors:  R G Spiro; V D Bhoyroo
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Authors:  Benjamin J Gross; Brian C Kraybill; Suzanne Walker
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  19 in total

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6.  Metabolic inhibition of sialyl-Lewis X biosynthesis by 5-thiofucose remodels the cell surface and impairs selectin-mediated cell adhesion.

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Review 7.  Biological functions of fucose in mammals.

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10.  Metabolic inhibitors of bacterial glycan biosynthesis.

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