Literature DB >> 22095352

Beyond base pairs to bedside: a population perspective on how genomics can improve health.

Muin J Khoury1, Marta Gwinn, M Scott Bowen, W David Dotson.   

Abstract

A decade after the sequencing of the human genome, the National Human Genome Research Institute announced a strategic plan for genomic medicine. It calls for evaluating the structure and biology of genomes, understanding the biology of disease, advancing the science of medicine, and improving the effectiveness of health care. Fulfilling the promise of genomics urgently requires a population perspective to complement the bench-to-bedside model of translation. A population approach should assess the contribution of genomics to health in the context of social and environmental determinants of disease; evaluate genomic applications that may improve health care; design strategies for integrating genomics into practice; address ethical, legal, and social issues; and measure the population health impact of new technologies.

Entities:  

Mesh：

Year:  2011        PMID： 22095352      PMCID： PMC3490552          DOI： 10.2105/AJPH.2011.300299

Source DB:  PubMed          Journal:  Am J Public Health        ISSN： 0090-0036            Impact factor:   9.308


  34 in total

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  23 in total

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Journal:  Am J Med Genet C Semin Med Genet       Date:  2014-03-13       Impact factor: 3.908

5.  Mapping the Ethics of Translational Genomics: Situating Return of Results and Navigating the Research-Clinical Divide.

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6.  Concerns about unintended negative consequences of informing the public about multifactorial risks may be premature for young adult smokers.

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7.  Community leaders' perspectives on engaging African Americans in biobanks and other human genetics initiatives.

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Review 9.  Translating rare-disease therapies into improved care for patients and families: what are the right outcomes, designs, and engagement approaches in health-systems research?

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