Literature DB >> 22095064

Linking neurodevelopmental and synaptic theories of mental illness through DISC1.

Nicholas J Brandon1, Akira Sawa.   

Abstract

Recent advances in our understanding of the underlying genetic architecture of psychiatric disorders has blown away the diagnostic boundaries that are defined by currently used diagnostic manuals. The disrupted in schizophrenia 1 (DISC1) gene was originally discovered at the breakpoint of an inherited chromosomal translocation, which segregates with major mental illnesses. In addition, many biological studies have indicated a role for DISC1 in early neurodevelopment and synaptic regulation. Given that DISC1 is thought to drive a range of endophenotypes that underlie major mental conditions, elucidating the biology of DISC1 may enable the construction of new diagnostic categories for mental illnesses with a more meaningful biological foundation.

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Year:  2011        PMID： 22095064      PMCID： PMC3954824          DOI： 10.1038/nrn3120

Source DB:  PubMed          Journal:  Nat Rev Neurosci        ISSN： 1471-003X            Impact factor:   34.870


  197 in total

1.  Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression.

Authors:  Marcie Colledge; Eric M Snyder; Robert A Crozier; Jacquelyn A Soderling; Yetao Jin; Lorene K Langeberg; Hua Lu; Mark F Bear; John D Scott
Journal:  Neuron       Date:  2003-10-30       Impact factor: 17.173

2.  Yeast two-hybrid screens implicate DISC1 in brain development and function.

Authors:  J Kirsty Millar; Sheila Christie; David J Porteous
Journal:  Biochem Biophys Res Commun       Date:  2003-11-28       Impact factor: 3.575

3.  Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects.

Authors:  William Hennah; Teppo Varilo; Marjo Kestilä; Tiina Paunio; Ritva Arajärvi; Jari Haukka; Alex Parker; Rory Martin; Steve Levitzky; Timo Partonen; Joanne Meyer; Jouko Lönnqvist; Leena Peltonen; Jesper Ekelund
Journal:  Hum Mol Genet       Date:  2003-10-07       Impact factor: 6.150

4.  Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry.

Authors:  Junmin Peng; Myung Jong Kim; Dongmei Cheng; Duc M Duong; Steven P Gygi; Morgan Sheng
Journal:  J Biol Chem       Date:  2004-03-12       Impact factor: 5.157

Review 5.  Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteria.

Authors:  Michael F Green; Keith H Nuechterlein; James M Gold; Deanna M Barch; Jonathan Cohen; Susan Essock; Wayne S Fenton; Fred Frese; Terry E Goldberg; Robert K Heaton; Richard S E Keefe; Robert S Kern; Helena Kraemer; Ellen Stover; Daniel R Weinberger; Steven Zalcman; Stephen R Marder
Journal:  Biol Psychiatry       Date:  2004-09-01       Impact factor: 13.382

6.  Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder.

Authors:  Colin A Hodgkinson; David Goldman; Judith Jaeger; Shalini Persaud; John M Kane; Robert H Lipsky; Anil K Malhotra
Journal:  Am J Hum Genet       Date:  2004-09-22       Impact factor: 11.025

7.  Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth.

Authors:  K Miyoshi; A Honda; K Baba; M Taniguchi; K Oono; T Fujita; S Kuroda; T Katayama; M Tohyama
Journal:  Mol Psychiatry       Date:  2003-07       Impact factor: 15.992

Review 8.  Microanatomy of dendritic spines: emerging principles of synaptic pathology in psychiatric and neurological disease.

Authors:  Thomas A Blanpied; Michael D Ehlers
Journal:  Biol Psychiatry       Date:  2004-06-15       Impact factor: 13.382

Review 9.  Clinical phenotypes associated with DISC1, a candidate gene for schizophrenia.

Authors:  D H R Blackwood; W J Muir
Journal:  Neurotox Res       Date:  2004       Impact factor: 3.911

10.  DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.

Authors:  Jill A Morris; Geeta Kandpal; Lei Ma; Christopher P Austin
Journal:  Hum Mol Genet       Date:  2003-07-01       Impact factor: 6.150
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  209 in total

1.  Psychiatric disorders: Multiple pathways to DISC1-related disease?

Authors:  Darran Yates
Journal:  Nat Rev Neurosci       Date:  2011-12-20       Impact factor: 34.870

2.  Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate.

Authors:  Priya Srikanth; Karam Han; Dana G Callahan; Eugenia Makovkina; Christina R Muratore; Matthew A Lalli; Honglin Zhou; Justin D Boyd; Kenneth S Kosik; Dennis J Selkoe; Tracy L Young-Pearse
Journal:  Cell Rep       Date:  2015-08-20       Impact factor: 9.423

3.  Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington's disease.

Authors:  Motomasa Tanaka; Koko Ishizuka; Yoko Nekooki-Machida; Ryo Endo; Noriko Takashima; Hideyuki Sasaki; Yusuke Komi; Amy Gathercole; Elaine Huston; Kazuhiro Ishii; Kelvin Kai-Wan Hui; Masaru Kurosawa; Sun-Hong Kim; Nobuyuki Nukina; Eiki Takimoto; Miles D Houslay; Akira Sawa
Journal:  J Clin Invest       Date:  2017-03-06       Impact factor: 14.808

4.  DISC1 and SLC12A2 interaction affects human hippocampal function and connectivity.

Authors:  Joseph H Callicott; Emer L Feighery; Venkata S Mattay; Michael G White; Qiang Chen; David A A Baranger; Karen F Berman; Bai Lu; Hongjun Song; Guo-li Ming; Daniel R Weinberger
Journal:  J Clin Invest       Date:  2013-07       Impact factor: 14.808

5.  Convergent brain microstructure across multiple genetic models of schizophrenia and autism spectrum disorder: A feasibility study.

Authors:  Brian R Barnett; Cameron P Casey; Maribel Torres-Velázquez; Paul A Rowley; John-Paul J Yu
Journal:  Magn Reson Imaging       Date:  2020-04-13       Impact factor: 2.546

6.  TAR DNA-Binding Protein 43 and Disrupted in Schizophrenia 1 Coaggregation Disrupts Dendritic Local Translation and Mental Function in Frontotemporal Lobar Degeneration.

Authors:  Ryo Endo; Noriko Takashima; Yoko Nekooki-Machida; Yusuke Komi; Kelvin Kai-Wan Hui; Masaki Takao; Hiroyasu Akatsu; Shigeo Murayama; Akira Sawa; Motomasa Tanaka
Journal:  Biol Psychiatry       Date:  2018-03-29       Impact factor: 13.382

7.  Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids.

Authors:  Minae Niwa; Hanna Jaaro-Peled; Stephanie Tankou; Saurav Seshadri; Takatoshi Hikida; Yurie Matsumoto; Nicola G Cascella; Shin-ichi Kano; Norio Ozaki; Toshitaka Nabeshima; Akira Sawa
Journal:  Science       Date:  2013-01-18       Impact factor: 47.728

Review 8.  Pre-clinical models of neurodevelopmental disorders: focus on the cerebellum.

Authors:  Alexey V Shevelkin; Chinezimuzo Ihenatu; Mikhail V Pletnikov
Journal:  Rev Neurosci       Date:  2014       Impact factor: 4.353

Review 9.  NDE1 and NDEL1: twin neurodevelopmental proteins with similar 'nature' but different 'nurture'.

Authors:  Nicholas J Bradshaw; William Hennah; Dinesh C Soares
Journal:  Biomol Concepts       Date:  2013-10

10.  Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: its downregulation by DISC1.

Authors:  Adriana Ramos; Carmen Rodríguez-Seoane; Isaac Rosa; Svenja V Trossbach; Alfredo Ortega-Alonso; Liisa Tomppo; Jesper Ekelund; Juha Veijola; Marjo-Riitta Järvelin; Jana Alonso; Sonia Veiga; Akira Sawa; William Hennah; Angel García; Carsten Korth; Jesús R Requena
Journal:  Hum Mol Genet       Date:  2014-06-16       Impact factor: 6.150
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