Maria Siemionow1, Can Ozturk. 1. Cleveland, Ohio From the Dermatology and Plastic Surgery Institute, Cleveland Clinic.
Abstract
BACKGROUND: Since 2005, 13 facial allotransplantation cases have been performed worldwide. The major indications for these facial allotransplantations were neurofibromatosis and trauma injuries, including animal bites, burns, falls, and shotgun blasts. METHODS: An analysis of 13 facial transplantation cases was performed by reviewing the anatomical details, microsurgical techniques, and functional outcomes according to the follow-up information based on the literature, meeting presentations, and media reports. RESULTS: The male-to-female ratio was 11:2. Two male patients died at 2 months and 2 years, respectively, after transplantation because of transplant- and infection-related problems. Eleven face transplant recipients are alive. The composite tissue allotransplants included cutaneous, myocutaneous, and osteomyocutaneous components. Most of these facial allotransplants were partial, one was nearly total, and two were announced as total face transplantations. CONCLUSIONS: This report provides a useful overview of the technical aspects of face transplantation; however, the reports on long-term functional and aesthetic outcomes will help to define the future of face transplantation.
BACKGROUND: Since 2005, 13 facial allotransplantation cases have been performed worldwide. The major indications for these facial allotransplantations were neurofibromatosis and trauma injuries, including animal bites, burns, falls, and shotgun blasts. METHODS: An analysis of 13 facial transplantation cases was performed by reviewing the anatomical details, microsurgical techniques, and functional outcomes according to the follow-up information based on the literature, meeting presentations, and media reports. RESULTS: The male-to-female ratio was 11:2. Two male patients died at 2 months and 2 years, respectively, after transplantation because of transplant- and infection-related problems. Eleven face transplant recipients are alive. The composite tissue allotransplants included cutaneous, myocutaneous, and osteomyocutaneous components. Most of these facial allotransplants were partial, one was nearly total, and two were announced as total face transplantations. CONCLUSIONS: This report provides a useful overview of the technical aspects of face transplantation; however, the reports on long-term functional and aesthetic outcomes will help to define the future of face transplantation.
Authors: Maria Lucia L Madariaga; Kumaran Shanmugarajah; Sebastian G Michel; Vincenzo Villani; Glenn M La Muraglia; Radbeh Torabi; David A Leonard; Mark A Randolph; Robert B Colvin; Kazuhiko Yamada; Joren C Madsen; Curtis L Cetrulo; David H Sachs Journal: Transplantation Date: 2015-08 Impact factor: 4.939
Authors: Ryan J Murphy; Chad R Gordon; Ehsan Basafa; Peter Liacouras; Gerald T Grant; Mehran Armand Journal: Int J Comput Assist Radiol Surg Date: 2014-09-18 Impact factor: 2.924
Authors: J Rodrigo Diaz-Siso; Ericka M Bueno; Geoffroy C Sisk; Francisco M Marty; Bohdan Pomahac; Stefan G Tullius Journal: Clin Transplant Date: 2013-04-14 Impact factor: 2.863
Authors: Jonas T Schnider; Matthias Weinstock; Jan A Plock; Mario G Solari; Raman Venkataramanan; Xin Xiao Zheng; Vijay S Gorantla Journal: Clin Dev Immunol Date: 2013-02-13