Literature DB >> 22094356

Summary of Product Characteristics content extraction for a safe drugs usage.

S Rubrichi1, S Quaglini.   

Abstract

The use of medications has a central role in health care provision, yet on occasion, it may injure the person taking them as result of adverse drug events. A correct drug choice must be modulated to acknowledge both patients' status and drug-specific information. However, this information is locked in free-text and, as such, cannot be actively accessed and elaborated by computerized applications. The goal of this work lies in extracting content (active ingredient, interaction effects, etc.) from the Summary of Product Characteristics, focusing mainly on drug-related interactions, following a machine learning based approach. We compare two state of the art classifiers: conditional random fields with support vector machines. To this end, we introduce a corpus of 100 interaction sections, hand annotated with 13 labels that have been derived from a previously developed conceptual model. The results of our empirical analysis demonstrate that the two models perform well. They exhibit similar overall performance, with an overall accuracy of about 91%. Copyright Â
© 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID: 22094356     DOI: 10.1016/j.jbi.2011.10.012

Source DB:  PubMed          Journal:  J Biomed Inform        ISSN: 1532-0464            Impact factor:   6.317


  4 in total

1.  Semantic processing to identify adverse drug event information from black box warnings.

Authors:  Adam Culbertson; Marcelo Fiszman; Dongwook Shin; Thomas C Rindflesch
Journal:  AMIA Annu Symp Proc       Date:  2014-11-14

2.  Dynamic enhancement of drug product labels to support drug safety, efficacy, and effectiveness.

Authors:  Richard D Boyce; John R Horn; Oktie Hassanzadeh; Anita de Waard; Jodi Schneider; Joanne S Luciano; Majid Rastegar-Mojarad; Maria Liakata
Journal:  J Biomed Semantics       Date:  2013-01-26

3.  Knowledge Discovery from Posts in Online Health Communities Using Unified Medical Language System.

Authors:  Donghua Chen; Runtong Zhang; Kecheng Liu; Lei Hou
Journal:  Int J Environ Res Public Health       Date:  2018-06-19       Impact factor: 3.390

4.  Annotation and detection of drug effects in text for pharmacovigilance.

Authors:  Paul Thompson; Sophia Daikou; Kenju Ueno; Riza Batista-Navarro; Jun'ichi Tsujii; Sophia Ananiadou
Journal:  J Cheminform       Date:  2018-08-13       Impact factor: 5.514

  4 in total

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