Literature DB >> 22093760

Synthesis of osteotropic hydroxybisphosphonate derivatives of fluoroquinolone antibacterials.

James C McPherson1, Royce Runner, Thomas B Buxton, John F Hartmann, Dan Farcasiu, Ilona Bereczki, Erzsébet Roth, Szilvia Tollas, Eszter Ostorházi, Ferenc Rozgonyi, Pál Herczegh.   

Abstract

1-Hydroxybisphosphonate derivatives of ciprofloxacin, gatifloxacin and moxifloxacin have been synthesized using Cu(I) catalyzed azide-alkyne 1,3-dipolar cycloaddition reaction. The 1,2,3-triazol linked hydroxybisphosphonate derivative of ciprofloxacin exhibited antibacterial activity comparable to the parent antibiotic and all fluoroquinolone-bisphosphonates displayed osteotropic properties in a bone model.
Copyright © 2011 Elsevier Masson SAS. All rights reserved.

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Year:  2011        PMID： 22093760     DOI： 10.1016/j.ejmech.2011.10.049

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  7 in total

1.  Design, Synthesis, and Antimicrobial Evaluation of a Novel Bone-Targeting Bisphosphonate-Ciprofloxacin Conjugate for the Treatment of Osteomyelitis Biofilms.

Authors:  Parish P Sedghizadeh; Shuting Sun; Adam F Junka; Eric Richard; Keivan Sadrerafi; Susan Mahabady; Neema Bakhshalian; Natalia Tjokro; Marzenna Bartoszewicz; Monika Oleksy; Patrycja Szymczyk; Mark W Lundy; Jeffrey D Neighbors; R Graham G Russell; Charles E McKenna; Frank H Ebetino
Journal:  J Med Chem       Date:  2017-02-13       Impact factor: 7.446

2.  New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization.

Authors:  Hamada H H Mohammed; Amer Ali Abd El-Hafeez; Kareem Ebeid; Aml I Mekkawy; Mohammed A S Abourehab; Emad I Wafa; Suhaila O Alhaj-Suliman; Aliasger K Salem; Pradipta Ghosh; Gamal El-Din A Abuo-Rahma; Alaa M Hayallah; Samar H Abbas
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.756

3.  Bisphosphonates in dentistry: Historical perspectives, adverse effects, and novel applications.

Authors:  Parish P Sedghizadeh; Shuting Sun; Allan C Jones; Esmat Sodagar; Philip Cherian; Casey Chen; Adam F Junka; Jeffrey D Neighbors; Charles E McKenna; R Graham G Russell; Frank H Ebetino
Journal:  Bone       Date:  2021-03-20       Impact factor: 4.626

4.  Synthesis and biological evaluation of a new polymeric conjugate and nanocarrier with osteotropic properties.

Authors:  Rosario Pignatello; Maria Grazia Sarpietro; Francesco Castelli
Journal:  J Funct Biomater       Date:  2012-01-19

Review 5.  Modifications of quinolones and fluoroquinolones: hybrid compounds and dual-action molecules.

Authors:  Joanna Fedorowicz; Jarosław Sączewski
Journal:  Monatsh Chem       Date:  2018-06-07       Impact factor: 1.451

6.  Ciprofloxacin-Tethered 1,2,3-Triazole Conjugates: New Quinolone Family Compounds to Upgrade Our Antiquated Approach against Bacterial Infections.

Authors:  Alka Agarwal; Preeti Singh; Anand Maurya; Upendra Kumar Patel; Alka Singh; Gopal Nath
Journal:  ACS Omega       Date:  2022-01-11

7.  Directing Drugs to Bugs: Antibiotic-Carbohydrate Conjugates Targeting Biofilm-Associated Lectins of Pseudomonas aeruginosa.

Authors:  Joscha Meiers; Eva Zahorska; Teresa Röhrig; Dirk Hauck; Stefanie Wagner; Alexander Titz
Journal:  J Med Chem       Date:  2020-10-02       Impact factor: 7.446
  7 in total

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