BACKGROUND: Neurological outcome after cardiac arrest (CA) is difficult to predict in the acute phase. In this pilot study, we assessed blood levels of tau protein as a prognostic marker for the neurological outcome after 6 months in patients treated with hypothermia after resuscitation from CA. METHODS: 22 unconscious patients resuscitated after CA were treated with mild hypothermia (32-34°C) for 26 h. Blood samples were collected at 2, 6, 12, 24, 48, and 96 h after CA, and the concentration of tau protein was analyzed. Neurological outcome was assessed with the Glasgow-Pittsburgh cerebral performance category (CPC) scale at intensive care unit (ICU) discharge and after 6 months. The higher of the two CPC scores was used. RESULTS: At ICU discharge, 21/22 patients were alive, of whom 10 had a good (CPC 1-2) outcome. After 6 months, 15/22 patients were alive, of whom 14 had a good outcome. Tau protein levels were higher among those with a poor outcome at 48 h and 96 h. At 96 h sampling, tau concentration predicted a poor outcome (CPC 3-5) with a sensitivity of 71% and a specificity of 93%. CONCLUSIONS: Although in a pilot study, a late increase in plasma tau protein seems to be associated with a worse outcome after hypothermia treatment after CA, although more studies are needed. 2011 The Authors. Acta Anaesthesiologica Scandinavica, 2011 The Acta Anaesthesiologica Scandinavica Foundation.
BACKGROUND: Neurological outcome after cardiac arrest (CA) is difficult to predict in the acute phase. In this pilot study, we assessed blood levels of tau protein as a prognostic marker for the neurological outcome after 6 months in patients treated with hypothermia after resuscitation from CA. METHODS: 22 unconscious patients resuscitated after CA were treated with mild hypothermia (32-34°C) for 26 h. Blood samples were collected at 2, 6, 12, 24, 48, and 96 h after CA, and the concentration of tau protein was analyzed. Neurological outcome was assessed with the Glasgow-Pittsburgh cerebral performance category (CPC) scale at intensive care unit (ICU) discharge and after 6 months. The higher of the two CPC scores was used. RESULTS: At ICU discharge, 21/22 patients were alive, of whom 10 had a good (CPC 1-2) outcome. After 6 months, 15/22 patients were alive, of whom 14 had a good outcome. Tau protein levels were higher among those with a poor outcome at 48 h and 96 h. At 96 h sampling, tau concentration predicted a poor outcome (CPC 3-5) with a sensitivity of 71% and a specificity of 93%. CONCLUSIONS: Although in a pilot study, a late increase in plasma tau protein seems to be associated with a worse outcome after hypothermia treatment after CA, although more studies are needed. 2011 The Authors. Acta Anaesthesiologica Scandinavica, 2011 The Acta Anaesthesiologica Scandinavica Foundation.
Authors: D Larry Sparks; Richard J Kryscio; Marwan N Sabbagh; Chuck Ziolkowski; Yushun Lin; Lisa M Sparks; Carolyn Liebsack; Sherry Johnson-Traver Journal: Am J Neurodegener Dis Date: 2012-05-15
Authors: Alexis A Topjian; Robert A Berg; Joost J L M Bierens; Christine M Branche; Robert S Clark; Hans Friberg; Cornelia W E Hoedemaekers; Michael Holzer; Laurence M Katz; Johannes T A Knape; Patrick M Kochanek; Vinay Nadkarni; Johannes G van der Hoeven; David S Warner Journal: Neurocrit Care Date: 2012-12 Impact factor: 3.210
Authors: Niklas Mattsson; Henrik Zetterberg; Niklas Nielsen; Kaj Blennow; Josef Dankiewicz; Hans Friberg; Gisela Lilja; Philip S Insel; Christian Rylander; Pascal Stammet; Anders Aneman; Christian Hassager; Jesper Kjaergaard; Michael Kuiper; Tommaso Pellis; Jørn Wetterslev; Matthew Wise; Tobias Cronberg Journal: Ann Neurol Date: 2017-11-02 Impact factor: 10.422