BACKGROUND: Growth velocities during infancy might affect the risk of asthma in childhood. This study examines the association between peak height and weight velocities during the first 2 years of life and onset of asthma and wheeze up to 10 years of age. METHODS: Data from 9086 children who participated in the GINIplus and LISAplus birth cohorts were analyzed. Information on asthma was requested annually from 1 to 10 years and information on wheeze at 1, 2, 4, 6, and 10 years. Peak height and weight velocities were calculated using height and weight measurements obtained between birth and 2 years of age. Cox proportional hazards models and generalized linear mixed models were calculated after adjustment for potential confounding factors including birth weight and body mass index at 10 years of age. RESULTS: Per interquartile range increase in peak weight velocity (PWV), the risk of asthma increased significantly (adjHR: 1.22; CI: 1.02-1.47). The relationship between peak height velocity (PHV) and onset of asthma was nonsignificant (adjHR: 1.08; CI: 0.88-1.31). Wheeze was not significantly associated with PHV or with PWV (adjOR: 1.07; CI: 0.64-1.77 and adjOR: 1.11; CI: 0.68-1.79, respectively). CONCLUSIONS: Weight gain during infancy is positively associated with physician-diagnosed asthma in school-aged children.
BACKGROUND: Growth velocities during infancy might affect the risk of asthma in childhood. This study examines the association between peak height and weight velocities during the first 2 years of life and onset of asthma and wheeze up to 10 years of age. METHODS: Data from 9086 children who participated in the GINIplus and LISAplus birth cohorts were analyzed. Information on asthma was requested annually from 1 to 10 years and information on wheeze at 1, 2, 4, 6, and 10 years. Peak height and weight velocities were calculated using height and weight measurements obtained between birth and 2 years of age. Cox proportional hazards models and generalized linear mixed models were calculated after adjustment for potential confounding factors including birth weight and body mass index at 10 years of age. RESULTS: Per interquartile range increase in peak weight velocity (PWV), the risk of asthma increased significantly (adjHR: 1.22; CI: 1.02-1.47). The relationship between peak height velocity (PHV) and onset of asthma was nonsignificant (adjHR: 1.08; CI: 0.88-1.31). Wheeze was not significantly associated with PHV or with PWV (adjOR: 1.07; CI: 0.64-1.77 and adjOR: 1.11; CI: 0.68-1.79, respectively). CONCLUSIONS: Weight gain during infancy is positively associated with physician-diagnosed asthma in school-aged children.
Authors: C Flexeder; E Thiering; J Kratzsch; C Klümper; B Koletzko; M J Müller; S Koletzko; J Heinrich Journal: Eur J Clin Nutr Date: 2013-10-30 Impact factor: 4.016
Authors: Jean Bousquet; James E Gern; Fernando D Martinez; Josep M Anto; Christine C Johnson; Patrick G Holt; Robert F Lemanske; Peter N Le Souëf; Robert S Tepper; Erika R M von Mutius; S Hasan Arshad; Leonard B Bacharier; Allan Becker; Kathleen Belanger; Anna Bergström; David I Bernstein; Michael D Cabana; Kecia N Carroll; Mario Castro; Philip J Cooper; Matthew W Gillman; Diane R Gold; John Henderson; Joachim Heinrich; Soo-Jong Hong; Daniel J Jackson; Thomas Keil; Anita L Kozyrskyj; Karin C Lødrup Carlsen; Rachel L Miller; Isabelle Momas; Wayne J Morgan; Patricia Noel; Dennis R Ownby; Mariona Pinart; Patrick H Ryan; Julie M Schwaninger; Malcolm R Sears; Angela Simpson; Henriette A Smit; Debra A Stern; Padmaja Subbarao; Rudolf Valenta; Xiaobin Wang; Scott T Weiss; Robert Wood; Anne L Wright; Rosalind J Wright; Alkis Togias; Peter J Gergen Journal: J Allergy Clin Immunol Date: 2014-03-15 Impact factor: 10.793
Authors: Maria C Magnus; Hein Stigum; Siri E Håberg; Per Nafstad; Stephanie J London; Wenche Nystad Journal: PLoS One Date: 2015-01-30 Impact factor: 3.240
Authors: Agnes M M Sonnenschein-van der Voort; Laura D Howe; Raquel Granell; Liesbeth Duijts; Jonathan A C Sterne; Kate Tilling; A John Henderson Journal: J Allergy Clin Immunol Date: 2015-01-08 Impact factor: 10.793
Authors: Z Pei; C Flexeder; E Fuertes; E Thiering; B Koletzko; C Cramer; D Berdel; I Lehmann; C-P Bauer; J Heinrich Journal: Eur J Clin Nutr Date: 2013-04-24 Impact factor: 4.016