Literature DB >> 22090130

Genetic informational RNA is not required for recombinant prion infectivity.

Fei Wang1, Zhihong Zhang, Xinhe Wang, Jiali Li, Liang Zha, Chong-Gang Yuan, Charles Weissmann, Jiyan Ma.   

Abstract

Whether a genetic informational nucleic acid is required for the infectivity of transmissible spongiform encephalopathies is central to the debate about the infectious agent. Here we report that an infectious prion formed with bacterially expressed recombinant prion protein plus synthetic polyriboadenylic acid and synthetic phospholipid 1-palmitoyl-2-oleoylphosphatidylglycerol is competent to infect cultured cells and cause prion disease in wild-type mice. Our results show that genetic informational RNA is not required for recombinant prion infectivity.

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Year:  2011        PMID： 22090130      PMCID： PMC3264365          DOI： 10.1128/JVI.06216-11

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  18 in total

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