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Literature DB >> 22090122

Transmissible gastroenteritis coronavirus RNA-dependent RNA polymerase and nonstructural proteins 2, 3, and 8 are incorporated into viral particles.

Aitor Nogales¹, Silvia Márquez-Jurado, Carmen Galán, Luis Enjuanes, Fernando Almazán.

Abstract

Coronavirus replication and transcription are processes mediated by a protein complex, with the RNA-dependent RNA polymerase (RdRp) as a main component. Proteomic analysis of highly purified transmissible gastroenteritis virus showed the RdRp to be a component of the viral particles. This finding was confirmed by Western blotting, immunofluorescence, and immunoelectron microscopy analyses. Interestingly, the replicase nonstructural proteins 2, 3, and 8 colocalized with the RdRp in the viral factories and were also incorporated into the virions.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2011 PMID： 22090122 PMCID： PMC3255853 DOI： 10.1128/JVI.06428-11

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

24 in total

1. Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex.

Authors: Eric J Snijder; Yvonne van der Meer; Jessika Zevenhoven-Dobbe; Jos J M Onderwater; Jannes van der Meulen; Henk K Koerten; A Mieke Mommaas
Journal: J Virol Date: 2006-06 Impact factor: 5.103

2. Identification of an immunodominant epitope in the C terminus of glycoprotein 5 of porcine reproductive and respiratory syndrome virus.

Authors: María Jose Rodriguez; Javier Sarraseca; Jesús Fominaya; Elena Cortés; Antonio Sanz; J Ignacio Casal
Journal: J Gen Virol Date: 2001-05 Impact factor: 3.891

3. RNA replication of mouse hepatitis virus takes place at double-membrane vesicles.

Authors: Rainer Gosert; Amornrat Kanjanahaluethai; Denise Egger; Kurt Bienz; Susan C Baker
Journal: J Virol Date: 2002-04 Impact factor: 5.103

Review 4. Biochemical aspects of coronavirus replication and virus-host interaction.

Authors: Luis Enjuanes; Fernando Almazán; Isabel Sola; Sonia Zuñiga
Journal: Annu Rev Microbiol Date: 2006 Impact factor: 15.500

5. Selective replication of coronavirus genomes that express nucleocapsid protein.

Authors: Barbara Schelle; Nadja Karl; Burkhard Ludewig; Stuart G Siddell; Volker Thiel
Journal: J Virol Date: 2005-06 Impact factor: 5.103

6. Membrane protein molecules of transmissible gastroenteritis coronavirus also expose the carboxy-terminal region on the external surface of the virion.

Authors: C Risco; I M Antón; C Suñé; A M Pedregosa; J M Martín-Alonso; F Parra; J L Carrascosa; L Enjuanes
Journal: J Virol Date: 1995-09 Impact factor: 5.103

Review 7. RNA-RNA and RNA-protein interactions in coronavirus replication and transcription.

Authors: Isabel Sola; Pedro A Mateos-Gomez; Fernando Almazan; Sonia Zuñiga; Luis Enjuanes
Journal: RNA Biol Date: 2011-03-01 Impact factor: 4.652

8. Immunogenic characterization and epitope mapping of transmissible gastroenteritis virus RNA dependent RNA polymerase.

Authors: Aitor Nogales; Carmen Galán; Silvia Márquez-Jurado; Mónica García-Gallo; Leonor Kremer; Luis Enjuanes; Fernando Almazán
Journal: J Virol Methods Date: 2011-04-12 Impact factor: 2.014

9. Absence of E protein arrests transmissible gastroenteritis coronavirus maturation in the secretory pathway.

Authors: Javier Ortego; Juan E Ceriani; Cristina Patiño; Juan Plana; Luis Enjuanes
Journal: Virology Date: 2007-08-10 Impact factor: 3.616

10. Host cell proteins interacting with the 3' end of TGEV coronavirus genome influence virus replication.

Authors: Carmen Galán; Isabel Sola; Aitor Nogales; Benjamin Thomas; Alexandre Akoulitchev; Luis Enjuanes; Fernando Almazán
Journal: Virology Date: 2009-07-05 Impact factor: 3.616

10 in total

Review 1. Continuous and Discontinuous RNA Synthesis in Coronaviruses.

Authors: Isabel Sola; Fernando Almazán; Sonia Zúñiga; Luis Enjuanes
Journal: Annu Rev Virol Date: 2015-11 Impact factor: 10.431

2. The proteome of the infectious bronchitis virus Beau-R virion.

Authors: Stuart D Dent; Dong Xia; Jonathan M Wastling; Benjamin W Neuman; Paul Britton; Helena J Maier
Journal: J Gen Virol Date: 2015-12 Impact factor: 3.891

3. Highly divergent strains of porcine reproductive and respiratory syndrome virus incorporate multiple isoforms of nonstructural protein 2 into virions.

Authors: Matthew A Kappes; Cathy L Miller; Kay S Faaberg
Journal: J Virol Date: 2013-10-02 Impact factor: 5.103

4. Mutagenesis of Coronavirus nsp14 Reveals Its Potential Role in Modulation of the Innate Immune Response.

Authors: Martina Becares; Alejandro Pascual-Iglesias; Aitor Nogales; Isabel Sola; Luis Enjuanes; Sonia Zuñiga
Journal: J Virol Date: 2016-05-12 Impact factor: 5.103

Review 5. Temperature Sensitive Mutations in Influenza A Viral Ribonucleoprotein Complex Responsible for the Attenuation of the Live Attenuated Influenza Vaccine.

Authors: Luis Martínez-Sobrido; Olve Peersen; Aitor Nogales
Journal: Viruses Date: 2018-10-15 Impact factor: 5.048

6. Decline of transmissible gastroenteritis virus and its complex evolutionary relationship with porcine respiratory coronavirus in the United States.

Authors: Fangzhou Chen; Todd P Knutson; Stephanie Rossow; Linda J Saif; Douglas G Marthaler
Journal: Sci Rep Date: 2019-03-08 Impact factor: 4.379

Review 10. Looking for a needle in a haystack: Cellular proteins that may interact with the tyrosine-based sorting signal of the TGEV S protein.

Authors: Anna Trincone; Christel Schwegmann-Weßels
Journal: Virus Res Date: 2014-12-04 Impact factor: 3.303