Literature DB >> 22090116

Lack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals.

Jaclyn K Wright1, Zabrina L Brumme, Boris Julg, Mary van der Stok, Zenele Mncube, Xiaojiang Gao, Jonathan M Carlson, Philip J R Goulder, Bruce D Walker, Mark A Brockman, Thumbi Ndung'u.   

Abstract

It is unknown whether favorable HLA class II alleles may attenuate HIV-1 through selection pressure in a manner similar to that of protective HLA class I alleles. We investigated the relationship between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals. No associations were found between individual alleles and lower replication capacity, suggesting no significant HIV-1 attenuation by HLA class II-restricted Gag-specific CD4(+) T cell immune pressure.

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Year:  2011        PMID： 22090116      PMCID： PMC3255856          DOI： 10.1128/JVI.06533-11

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  30 in total

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Journal:  J Virol       Date:  2007-08-29       Impact factor: 5.103

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Journal:  J Virol       Date:  2006-04       Impact factor: 5.103

9.  HIV-1 variation diminishes CD4 T lymphocyte recognition.

Authors:  G C Harcourt; S Garrard; M P Davenport; A Edwards; R E Phillips
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10.  Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag.

Authors:  Jonathan M Carlson; Zabrina L Brumme; Christine M Rousseau; Chanson J Brumme; Philippa Matthews; Carl Kadie; James I Mullins; Bruce D Walker; P Richard Harrigan; Philip J R Goulder; David Heckerman
Journal:  PLoS Comput Biol       Date:  2008-11-21       Impact factor: 4.475
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4.  HLA Class-II Associated HIV Polymorphisms Predict Escape from CD4+ T Cell Responses.

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  4 in total

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