Eleni P Katana1, Lemonia G Skoura, Zacharias G Scouras, Michail A Daniilidis. 1. Department of Genetics, Development, and Molecular Biology, School of Biology, Faculty of Sciences, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece. eleni.katana@gmail.com
Abstract
BACKGROUND: Heme oxygenase-1 (HO-1) is an enzyme, which catabolizes heme into carbon monoxide, biliverdin and free iron. The induction of this enzyme is an important cytoprotective mechanism, which occurs as an adaptive and beneficial response to a wide variety of oxidant stimuli. HO-1 inducibility is mainly modulated by a (GT)(n) polymorphism in the promoter region, and has been shown that short (S) repeats are associated with greater up-regulation of HO-1, compared with long (L) repeats. METHODS: In the present study, 250 healthy Greek individuals have been screened in order to estimate the frequencies of (GT)(n) alleles in the HO-1 gene. RESULTS: Nineteen different alleles, ranging from 17 to 39 repeats, with (GT)(23) and (GT)(30) being the most common ones, were identified. CONCLUSION: The possible role of this polymorphism in disease states is discussed.
BACKGROUND:Heme oxygenase-1 (HO-1) is an enzyme, which catabolizes heme into carbon monoxide, biliverdin and free iron. The induction of this enzyme is an important cytoprotective mechanism, which occurs as an adaptive and beneficial response to a wide variety of oxidant stimuli. HO-1 inducibility is mainly modulated by a (GT)(n) polymorphism in the promoter region, and has been shown that short (S) repeats are associated with greater up-regulation of HO-1, compared with long (L) repeats. METHODS: In the present study, 250 healthy Greek individuals have been screened in order to estimate the frequencies of (GT)(n) alleles in the HO-1 gene. RESULTS: Nineteen different alleles, ranging from 17 to 39 repeats, with (GT)(23) and (GT)(30) being the most common ones, were identified. CONCLUSION: The possible role of this polymorphism in disease states is discussed.
Authors: Helle H Hansson; Lasse Maretty; Christina Balle; Bamenla Q Goka; Elisa Luzon; Francis N Nkrumah; Mette L Schousboe; Onike P Rodrigues; Ib Christian Bygbjerg; Jørgen A L Kurtzhals; Michael Alifrangis; Casper Hempel Journal: Malar J Date: 2015-04-11 Impact factor: 2.979