BACKGROUND: The overall incidence and risk of nail changes associated with the use of epidermal growth factor receptor inhibitors (EGFRIs) varies widely across the literature. OBJECTIVE: We conducted a systematic review of the literature and performed a meta-analysis to determine the risk of developing nail toxicity among patients receiving EGFRIs. METHODS: Databases from Pubmed and Web of Science from January 1998 until July 2011 and abstracts presented at the American Society of Clinical Oncology annual meetings from 2004 through July 2011 were searched to identify relevant studies. The incidence and relative risk (RR) of nail toxicity were calculated using random-effects or fixed-effects model depending on the heterogeneity of the included studies. RESULTS: A total of 2107 patients from 22 clinical trials were included in this analysis. The overall incidence of all-grade nail toxicity was 17.2% (95% confidence interval [CI]: 13.8%-21.3%), with an RR of 76.94 (95% CI: 40.76-145.22, P < .001). The overall incidence of high-grade nail toxicity was 1.4% (95% CI: 0.9%-2.1%), with an RR of 13.11 (95% CI: 3.73-46.03, P < .001). LIMITATIONS: The ability to detect and grade nail changes may vary among institutions. CONCLUSION: There is a significant risk of developing nail toxicity in cancer patients receiving EGFRIs. The risk is independent of the underlying agent. Adequate monitoring and early intervention are recommended to prevent debilitating toxicity and suboptimal dosing of EGFRI.
BACKGROUND: The overall incidence and risk of nail changes associated with the use of epidermal growth factor receptor inhibitors (EGFRIs) varies widely across the literature. OBJECTIVE: We conducted a systematic review of the literature and performed a meta-analysis to determine the risk of developing nail toxicity among patients receiving EGFRIs. METHODS: Databases from Pubmed and Web of Science from January 1998 until July 2011 and abstracts presented at the American Society of Clinical Oncology annual meetings from 2004 through July 2011 were searched to identify relevant studies. The incidence and relative risk (RR) of nail toxicity were calculated using random-effects or fixed-effects model depending on the heterogeneity of the included studies. RESULTS: A total of 2107 patients from 22 clinical trials were included in this analysis. The overall incidence of all-grade nail toxicity was 17.2% (95% confidence interval [CI]: 13.8%-21.3%), with an RR of 76.94 (95% CI: 40.76-145.22, P < .001). The overall incidence of high-grade nail toxicity was 1.4% (95% CI: 0.9%-2.1%), with an RR of 13.11 (95% CI: 3.73-46.03, P < .001). LIMITATIONS: The ability to detect and grade nail changes may vary among institutions. CONCLUSION: There is a significant risk of developing nail toxicity in cancerpatients receiving EGFRIs. The risk is independent of the underlying agent. Adequate monitoring and early intervention are recommended to prevent debilitating toxicity and suboptimal dosing of EGFRI.
Authors: Mario E Lacouture; David J Kopsky; Raphael Lilker; Fiona Damstra; Mecheline H M van der Linden; Azael Freites-Martinez; Mischa P M Nagel Journal: J Am Podiatr Med Assoc Date: 2018-11
Authors: Gregory S Phillips; Azael Freites-Martinez; Meier Hsu; Anna Skripnik Lucas; Dulce M Barrios; Kathryn Ciccolini; Michael A Marchetti; Liang Deng; Patricia L Myskowski; Erica H Lee; Alina Markova; Mario E Lacouture Journal: J Am Acad Dermatol Date: 2017-12-19 Impact factor: 11.527
Authors: G Fabbrocini; M C Annunziata; M Donnarumma; S Cacciapuoti; C Marasca; A Tosti Journal: Support Care Cancer Date: 2018-02-10 Impact factor: 3.603
Authors: Kara D Capriotti; Milan Anadkat; Jennifer Choi; Benjamin Kaffenberger; Beth McLellan; Samuel Barone; Oluwaseun Kukoyi; Shari Goldfarb; Mario Lacouture Journal: Invest New Drugs Date: 2019-06-26 Impact factor: 3.850