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Literature DB >> 22087869

Obesity and its impact on drug therapy: are we ready for this change?

Michael Neely¹, Stan Louie.

Abstract

Mesh：

Year: 2011 PMID： 22087869 DOI： 10.2165/11597120-000000000-00000

Source DB: PubMed Journal: Clin Pharmacokinet ISSN： 0312-5963 Impact factor: 6.447

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22 in total

1. Applications of physiologically based pharmacokinetic (PBPK) modeling and simulation during regulatory review.

Authors: P Zhao; L Zhang; J A Grillo; Q Liu; J M Bullock; Y J Moon; P Song; S S Brar; R Madabushi; T C Wu; B P Booth; N A Rahman; K S Reynolds; E Gil Berglund; L J Lesko; S-M Huang
Journal: Clin Pharmacol Ther Date: 2010-12-29 Impact factor: 6.875

Review 2. Evidence that the prevalence of childhood overweight is plateauing: data from nine countries.

Authors: Tim Olds; Carol Maher; Shi Zumin; Sandrine Péneau; Sandrine Lioret; Katia Castetbon; Jeroen de Wilde; Maea Hohepa; Ralph Maddison; Lauren Lissner; Agneta Sjöberg; Michael Zimmermann; Isabelle Aeberli; Cynthia Ogden; Katherine Flegal; Carolyn Summerbell
Journal: Int J Pediatr Obes Date: 2011-08-12

3. Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat.

Authors: Andreas Geier; Christoph G Dietrich; Tobias Grote; Ulrich Beuers; Thomas Prüfer; Peter Fraunberger; Siegfried Matern; Carsten Gartung; Alexander L Gerbes; Manfred Bilzer
Journal: J Hepatol Date: 2005-07-01 Impact factor: 25.083

Review 4. Dosing dilemmas in obese children.

Authors: H Mulla; T N Johnson
Journal: Arch Dis Child Educ Pract Ed Date: 2010-06-28 Impact factor: 1.309

5. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein.

Authors: G S Hotamisligil; R S Johnson; R J Distel; R Ellis; V E Papaioannou; B M Spiegelman
Journal: Science Date: 1996-11-22 Impact factor: 47.728

6. Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta.

Authors: Marc Le Vee; Philippe Gripon; Bruno Stieger; Olivier Fardel
Journal: Drug Metab Dispos Date: 2007-11-08 Impact factor: 3.922

Obesity and its impact on drug therapy: are we ready for this change?

1. Applications of physiologically based pharmacokinetic (PBPK) modeling and simulation during regulatory review.

Review 2. Evidence that the prevalence of childhood overweight is plateauing: data from nine countries.

3. Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat.

Review 4. Dosing dilemmas in obese children.

5. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein.

6. Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta.

7. Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes.

Review 8. Effect of obesity on the pharmacokinetics of drugs in humans.

9. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.

10. Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity.