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Literature DB >> 22085845

Inhibition of TNF-α stimulated nuclear factor-kappa B (NF-κB) activation by cyclometalated platinum(II) complexes.

Jia Liu¹, Raymond Wai-Yin Sun, Chung-Hang Leung, Chun-Nam Lok, Chi-Ming Che.

Abstract

Cyclometalated platinum(II) complexes [Pt(II)(C^N^N)(C≡NR)](+) (HC^N^N = 6-phenyl-2,2'-bipyridyl) display significant inhibition towards TNF-α stimulated NF-κB-dependent gene transcription at concentrations down to the micromolar range. This journal is © The Royal Society of Chemistry 2012

Entities: Chemical Gene

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Year: 2011 PMID： 22085845 DOI： 10.1039/c1cc15317j

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

4 in total

1. Mitogen signal-associated pathways, energy metabolism regulation, and mediation of tumor immunogenicity play essential roles in the cellular response of malignant pleural mesotheliomas to platinum-based treatment: a retrospective study.

Authors: Alexander Mathilakathu; Sabrina Borchert; Michael Wessolly; Elena Mairinger; Hendrik Beckert; Julia Steinborn; Thomas Hager; Daniel C Christoph; Jens Kollmeier; Jeremias Wohlschlaeger; Thomas Mairinger; Kurt Werner Schmid; Robert F H Walter; Luka Brcic; Fabian D Mairinger
Journal: Transl Lung Cancer Res Date: 2021-07

Inhibition of TNF-α stimulated nuclear factor-kappa B (NF-κB) activation by cyclometalated platinum(II) complexes.

1. Mitogen signal-associated pathways, energy metabolism regulation, and mediation of tumor immunogenicity play essential roles in the cellular response of malignant pleural mesotheliomas to platinum-based treatment: a retrospective study.

2. Anticancer osmium complex inhibitors of the HIF-1α and p300 protein-protein interaction.

3. NF-κB hijacking theranostic Pt(ll) complex in cancer therapy.

4. Identification of an iridium(III) complex with anti-bacterial and anti-cancer activity.