Rohen White1, Scott Donnellan, Trevor Leong. 1. Peter MacCallum Cancer Centre, East Melbourne Southern Health, Clayton, Australia. Rohen.White@petermac.org
Abstract
UNLABELLED: What's known on the subject? and What does the study add? Condyloma acuminatum of the bladder is a rare affliction and as such its ideal management is unknown. This manuscript describes curative treatment of severe disease with external beam radiotherapy concurrent with low dose chemotherapy, an approach which has not previously been utilised. OBJECTIVES: • To report the first occurrence of complete and sustained resolution of symptomatic condyloma acuminatum of the bladder with chemoradiotherapy. • To describe the relevant patient details, imaging findings and chemoradiation treatment. PATIENT AND METHOD: • A 54-year-old female with extensive condyloma acuminatum of the bladder and a long history of human papilloma virus related anogenital disease was diagnosed with anal squamous cell carcinoma. • Cystectomy for the bladder disease was delayed whilst chemoradiotherapy was administered for the anal cancer. RESULTS: • There was complete resolution of bladder disease at follow-up which has negated the need for cystectomy with its associated morbidity. • Condyloma acuminatum has not recurred in 4 years of follow-up. CONCLUSION: • This is the first published report to our knowledge of the successful treatment of condyloma acuminatum of the bladder with chemoradiotherapy. • The individual contributions of radiotherapy vs chemotherapy cannot be discerned.
UNLABELLED: What's known on the subject? and What does the study add? Condyloma acuminatum of the bladder is a rare affliction and as such its ideal management is unknown. This manuscript describes curative treatment of severe disease with external beam radiotherapy concurrent with low dose chemotherapy, an approach which has not previously been utilised. OBJECTIVES: • To report the first occurrence of complete and sustained resolution of symptomatic condyloma acuminatum of the bladder with chemoradiotherapy. • To describe the relevant patient details, imaging findings and chemoradiation treatment. PATIENT AND METHOD: • A 54-year-old female with extensive condyloma acuminatum of the bladder and a long history of human papilloma virus related anogenital disease was diagnosed with anal squamous cell carcinoma. • Cystectomy for the bladder disease was delayed whilst chemoradiotherapy was administered for the anal cancer. RESULTS: • There was complete resolution of bladder disease at follow-up which has negated the need for cystectomy with its associated morbidity. • Condyloma acuminatum has not recurred in 4 years of follow-up. CONCLUSION: • This is the first published report to our knowledge of the successful treatment of condyloma acuminatum of the bladder with chemoradiotherapy. • The individual contributions of radiotherapy vs chemotherapy cannot be discerned.