| Literature DB >> 22085112 |
Asadhawut Hiranrat1, Wilawan Mahabusarakam, Anthony R Carroll, Sandra Duffy, Vicky M Avery.
Abstract
Two phloroglucinols named tomentosones A and B (1 and 2) that each possess a novel hexacyclic ring system were isolated from the CH(2)Cl(2) extract of Rhodomyrtus tomentosa leaves. Their structures were elucidated from analyses of 2D NMR spectroscopic data. Tomentosone A inhibited the growth of chloroquine-resistant and -sensitive strains of the malaria parasite Plasmodium falciparum, with IC(50) values of 1.49 μM and 1.0 μM, respectively, while tomentosone B was significantly less active.Entities:
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Year: 2011 PMID： 22085112 DOI： 10.1021/jo201602y
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354