BACKGROUND: Histological risk assessment evaluating worst pattern of tumour invasion (WPOI), and lymphocytic response (LR), has previously been shown to be of prognostic significance in squamous cell carcinomas of the head and neck (SCCHN). SCCHN is a heterogeneous group of tumours including tumours located in the oral cavity, of which the majority is located in the tongue. METHODS: Haematoxylin/eosin-stained slides from diagnostic biopsies from 94 cases of SCC on the tongue were evaluated for WPOI and LR. Within the inflammatory infiltrate, the percentage of eosinophilic granulocytes was also estimated. Results were correlated with clinical data such as response to treatment and recurrence. RESULTS: For WPOI the majority of patients, 84%, showed small invasive tumours islands with a size <15 cells (grade 4). No correlation with survival, response to treatment or recurrence was seen for WPOI. More than half of the patients showed a dense lymphocytic infiltrate, a factor that was significantly correlated with complete response to radio therapy. Of the patients with dense lymphoid infiltrate, the majority, 63%, did not either have a recurrence. No significant correlation with recurrence, response to treatment or any other factor was seen for presence of eosinophils. CONCLUSIONS: Data clearly showed that tongue tumours have a split invasive growth pattern and an intense inflammatory response at the tumour interface. Results also indicated that evaluation of the intensity of the inflammatory infiltrate at the tumour interface in tongue SCC could provide information of potential importance for choice of treatment and prognosis.
BACKGROUND: Histological risk assessment evaluating worst pattern of tumour invasion (WPOI), and lymphocytic response (LR), has previously been shown to be of prognostic significance in squamous cell carcinomas of the head and neck (SCCHN). SCCHN is a heterogeneous group of tumours including tumours located in the oral cavity, of which the majority is located in the tongue. METHODS:Haematoxylin/eosin-stained slides from diagnostic biopsies from 94 cases of SCC on the tongue were evaluated for WPOI and LR. Within the inflammatory infiltrate, the percentage of eosinophilic granulocytes was also estimated. Results were correlated with clinical data such as response to treatment and recurrence. RESULTS: For WPOI the majority of patients, 84%, showed small invasive tumours islands with a size <15 cells (grade 4). No correlation with survival, response to treatment or recurrence was seen for WPOI. More than half of the patients showed a dense lymphocytic infiltrate, a factor that was significantly correlated with complete response to radio therapy. Of the patients with dense lymphoid infiltrate, the majority, 63%, did not either have a recurrence. No significant correlation with recurrence, response to treatment or any other factor was seen for presence of eosinophils. CONCLUSIONS: Data clearly showed that tongue tumours have a split invasive growth pattern and an intense inflammatory response at the tumour interface. Results also indicated that evaluation of the intensity of the inflammatory infiltrate at the tumour interface in tongue SCC could provide information of potential importance for choice of treatment and prognosis.
Authors: Alhadi Almangush; Ibrahim O Bello; Ricardo D Coletta; Antti A Mäkitie; Laura K Mäkinen; Joonas H Kauppila; Matti Pukkila; Jaana Hagström; Jussi Laranne; Ylermi Soini; Veli-Matti Kosma; Petri Koivunen; Natalie Kelner; Luiz Paulo Kowalski; Reidar Grénman; Ilmo Leivo; Esa Läärä; Tuula Salo Journal: Virchows Arch Date: 2015-04-03 Impact factor: 4.064
Authors: N Sgaramella; P J Coates; K Strindlund; L Loljung; G Colella; G Laurell; R Rossiello; L L Muzio; C Loizou; G Tartaro; K Olofsson; K Danielsson; R Fåhraeus; K Nylander Journal: Br J Cancer Date: 2015-06-09 Impact factor: 7.640
Authors: Nicola Sgaramella; Eva Lindell Jonsson; Linda Boldrup; Luigi Califano; Philip J Coates; Gianpaolo Tartaro; Lorenzo Lo Muzio; Robin Fåhraeus; Giuseppe Colella; Giovanni Dell'Aversana Orabona; Lotta Loljung; Mario Santagata; Riccardo Rossiello; Torben Wilms; Karin Danielsson; Göran Laurell; Karin Nylander Journal: J Pathol Clin Res Date: 2015-10-09
Authors: Alhadi Almangush; Ibrahim O Bello; Harri Keski-Säntti; Laura K Mäkinen; Joonas H Kauppila; Matti Pukkila; Jaana Hagström; Jussi Laranne; Satu Tommola; Outi Nieminen; Ylermi Soini; Veli-Matti Kosma; Petri Koivunen; Reidar Grénman; Ilmo Leivo; Tuula Salo Journal: Head Neck Date: 2013-09-02 Impact factor: 3.147