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Literature DB >> 22084239

Energetics of cyclic AMP binding to HCN channel C terminus reveal negative cooperativity.

Sarah S Chow¹, Filip Van Petegem, Eric A Accili.

Abstract

Cyclic AMP binds to the HCN channel C terminus and variably stabilizes its open state. Using isothermal titration calorimetry, we show that cAMP binds to one subunit of tetrameric HCN2 and HCN4 C termini with high affinity (∼0.12 μM) and subsequently with low affinity (∼1 μM) to the remaining three subunits. Changes induced by high affinity binding already exist in both a constrained HCN2 tetramer and the unconstrained HCN1 tetramer. Natural "preactivation" of HCN1 may explain both the smaller effect of cAMP on stabilizing its open state and the opening of unliganded HCN1, which occurs as though already disinhibited.

Entities: Chemical Gene

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Year: 2011 PMID： 22084239 PMCID： PMC3249114 DOI： 10.1074/jbc.M111.269563

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

34 in total

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