Literature DB >> 2208396

Synthesis of a new chemically stable prostacyclin analogue with high and long-lasting activity.

K Iseki1, T Kanayama, Y Hayasi, M Shibasaki.   

Abstract

The chemically stable prostacyclin analogue (Z)-4,5-didehydroisocarbacyclin analogue (6) has been synthesized. Compound 6 given intravenously or orally is very potent in inhibiting platelet aggregation.

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Year:  1990        PMID： 2208396     DOI： 10.1248/cpb.38.1769

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  1 in total

1.  Hydroboration-Oxidation of (±)-(1α,3α,3aβ,6aβ)-1,2,3,3a,4,6a-Hexahydro-1,3-pentalenedimethanol and Its O-Protected Derivatives: Synthesis of New Compounds Useful for Obtaining (iso)Carbacyclin Analogues and X-ray Analysis of the Products.

Authors:  Constantin I Tănase; Florea G Cocu; Miron Teodor Căproiu; Constantin Drăghici; Sergiu Shova
Journal:  Molecules       Date:  2017-11-24       Impact factor: 4.411
  1 in total

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