Literature DB >> 22083088

Gastrointestinal hormones: uroguanylin-a new gut-derived weapon against obesity?

Gema Frühbeck.   

Abstract

A recent report has identified uroguanylin as an endocrine signal that exerts a physiological role in energy homeostasis, adding another factor to the gut–brain axis. From a clinical point of view, several observations highlight the uroguanylin–guanylyl cyclase C pathway as a potential therapeutic target for the development of antiobesity drugs.

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Year:  2011        PMID： 22083088     DOI： 10.1038/nrendo.2011.206

Source DB:  PubMed          Journal:  Nat Rev Endocrinol        ISSN： 1759-5029            Impact factor:   43.330


  10 in total

1.  Role for the membrane receptor guanylyl cyclase-C in attention deficiency and hyperactive behavior.

Authors:  Rong Gong; Cheng Ding; Ji Hu; Yao Lu; Fei Liu; Elizabeth Mann; Fuqiang Xu; Mitchell B Cohen; Minmin Luo
Journal:  Science       Date:  2011-08-11       Impact factor: 47.728

Review 2.  Regulation and therapeutic targeting of peptide-activated receptor guanylyl cyclases.

Authors:  Lincoln R Potter
Journal:  Pharmacol Ther       Date:  2010-12-24       Impact factor: 12.310

3.  A uroguanylin-GUCY2C endocrine axis regulates feeding in mice.

Authors:  Michael A Valentino; Jieru E Lin; Adam E Snook; Peng Li; Gilbert W Kim; Glen Marszalowicz; Michael S Magee; Terry Hyslop; Stephanie Schulz; Scott A Waldman
Journal:  J Clin Invest       Date:  2011-08-25       Impact factor: 14.808

4.  Relation of addiction genes to hypothalamic gene changes subserving genesis and gratification of a classic instinct, sodium appetite.

Authors:  Wolfgang B Liedtke; Michael J McKinley; Lesley L Walker; Hao Zhang; Andreas R Pfenning; John Drago; Sarah J Hochendoner; Donald L Hilton; Andrew J Lawrence; Derek A Denton
Journal:  Proc Natl Acad Sci U S A       Date:  2011-07-11       Impact factor: 11.205

5.  Murine guanylate cyclase C regulates colonic injury and inflammation.

Authors:  Kris A Steinbrecher; Eleana Harmel-Laws; Monica P Garin-Laflam; Elizabeth A Mann; Lucas D Bezerra; Simon P Hogan; Mitchell B Cohen
Journal:  J Immunol       Date:  2011-05-09       Impact factor: 5.422

6.  An olfactory subsystem that detects carbon disulfide and mediates food-related social learning.

Authors:  Steven D Munger; Trese Leinders-Zufall; Lisa M McDougall; Renee E Cockerham; Andreas Schmid; Petra Wandernoth; Gunther Wennemuth; Martin Biel; Frank Zufall; Kevin R Kelliher
Journal:  Curr Biol       Date:  2010-07-15       Impact factor: 10.834

Review 7.  Effects of short-term food deprivation on orexin-A-induced intestinal bicarbonate secretion in comparison with related secretagogues.

Authors:  G Flemström; M W Bengtsson; K Mäkelä; K H Herzig
Journal:  Acta Physiol (Oxf)       Date:  2009-12-08       Impact factor: 6.311

8.  Release of endogenous opioids from duodenal enteroendocrine cells requires Trpm5.

Authors:  Zaza Kokrashvili; Deniliz Rodriguez; Valeriya Yevshayeva; Hang Zhou; Robert F Margolskee; Bedrich Mosinger
Journal:  Gastroenterology       Date:  2009-03-09       Impact factor: 22.682

9.  Uroguanylin knockout mice have increased blood pressure and impaired natriuretic response to enteral NaCl load.

Authors:  John N Lorenz; Michelle Nieman; Jenine Sabo; L Philip Sanford; Jennifer A Hawkins; Noeet Elitsur; Lara R Gawenis; Lane L Clarke; Mitchell B Cohen
Journal:  J Clin Invest       Date:  2003-10       Impact factor: 14.808

10.  The hormone receptor GUCY2C suppresses intestinal tumor formation by inhibiting AKT signaling.

Authors:  Jieru Egeria Lin; Peng Li; Adam Eugene Snook; Stephanie Schulz; Abhijit Dasgupta; Terry Marie Hyslop; Ahmara Vivian Gibbons; Glen Marszlowicz; Giovanni Mario Pitari; Scott Arthur Waldman
Journal:  Gastroenterology       Date:  2009-09-06       Impact factor: 22.682
  10 in total
  6 in total

1.  Guanylin and uroguanylin stimulate lipolysis in human visceral adipocytes.

Authors:  A Rodríguez; J Gómez-Ambrosi; V Catalán; S Ezquerro; L Méndez-Giménez; S Becerril; P Ibáñez; N Vila; M A Margall; R Moncada; V Valentí; C Silva; J Salvador; G Frühbeck
Journal:  Int J Obes (Lond)       Date:  2016-04-25       Impact factor: 5.095

2.  Immunohistochemical Staining for Uroguanylin, a Satiety Hormone, is Decreased in Intestinal Tissue Specimens From Female Adolescents With Obesity.

Authors:  Matthew D Di Guglielmo; Lacey Perdue; Adebowale Adeyemi; Kenneth L van Golen; Diana U Corao
Journal:  Pediatr Dev Pathol       Date:  2017-08-29

3.  Pilot Study Measuring the Novel Satiety Hormone, Pro-Uroguanylin, in Adolescents With and Without Obesity.

Authors:  Matthew D Di Guglielmo; Dalal Tonb; Zhaoping He; Adebowale Adeyemi; Kenneth L van Golen
Journal:  J Pediatr Gastroenterol Nutr       Date:  2018-03       Impact factor: 2.839

Review 4.  Pendrin, a novel transcriptional target of the uroguanylin system.

Authors:  Julia Rozenfeld; Osnat Tal; Orly Kladnitsky; Lior Adler; Edna Efrati; Stephen L Carrithers; Seth L Alper; Israel Zelikovic
Journal:  Cell Physiol Biochem       Date:  2013-12-18

5.  Guanylyl cyclase C and guanylin reduce fat droplet accumulation in cattle mesenteric adipose tissue.

Authors:  Masahiro Yasuda; Jyunya Kawabata; Sayaka Akieda-Asai; Tetsuo Nasu; Yukari Date
Journal:  J Vet Sci       Date:  2017-09-30       Impact factor: 1.672

Review 6.  Neurohormonal Changes in the Gut-Brain Axis and Underlying Neuroendocrine Mechanisms following Bariatric Surgery.

Authors:  Eirini Martinou; Irena Stefanova; Evangelia Iosif; Angeliki M Angelidi
Journal:  Int J Mol Sci       Date:  2022-03-19       Impact factor: 5.923
  6 in total

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