| Literature DB >> 2208302 |
N S Cai1, D D Li, H T Cheung, A Richardson.
Abstract
The expression of granulocyte/macrophage colony-stimulating factor (GM-CSF) was studied in spleen lymphocytes isolated from male C57BL/6J mice of 6, 20, and 29 months of age. GM-CSF expression (biological activity and mRNA level) was maximum after culturing the lymphocytes for 45 hr with concanavalin A and phorbol myristate acetate. The induction of both GM-CSF activity and mRNA levels was observed to decline over 60% between 6 and 29 months of age. The age-related decline in the level of GM-CSF paralleled the age-related decline in the mRNA levels of interleukin-2 and interleukin-3.Entities:
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Year: 1990 PMID： 2208302 DOI： 10.1016/0008-8749(90)90274-u
Source DB: PubMed Journal: Cell Immunol ISSN： 0008-8749 Impact factor: 4.868