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Literature DB >> 22082870

Impaired mitophagy at the heart of injury.

Roberta A Gottlieb¹, Robert M Mentzer, Phyllis-Jean Linton.

Abstract

Recent publications link mitophagy mediated by PINK1 and Parkin with cardioprotection and attenuation of inflammation and cell death. The field is in need of methods to monitor mitochondrial turnover in vivo to support the development of new therapies targeting mitochondrial turnover.

Entities: Disease Gene

Mesh：

Substances：

Year: 2011 PMID： 22082870 PMCID： PMC3288037 DOI： 10.4161/auto.7.12.18175

Source DB: PubMed Journal: Autophagy ISSN： 1554-8627 Impact factor: 16.016

7 in total

1. Heart failure in Parkinson's disease: analysis of the United States medicare current beneficiary survey.

Authors: T A Zesiewicz; J A Strom; A R Borenstein; R A Hauser; C R Cimino; H L Fontanet; G B Cintron; J F Staffetti; P B Dunne; K L Sullivan
Journal: Parkinsonism Relat Disord Date: 2004-10 Impact factor: 4.891

2. Stroke and Parkinson's disease.

Authors: R L Levine; J C Jones; N Bee
Journal: Stroke Date: 1992-06 Impact factor: 7.914

3. A role for mitochondria in NLRP3 inflammasome activation.

Authors: Rongbin Zhou; Amir S Yazdi; Philippe Menu; Jürg Tschopp
Journal: Nature Date: 2010-12-01 Impact factor: 49.962

4. PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function.

Authors: Filio Billia; Ludger Hauck; Filip Konecny; Vivek Rao; Jie Shen; Tak Wah Mak
Journal: Proc Natl Acad Sci U S A Date: 2011-05-23 Impact factor: 11.205

5. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome.

Authors: Kiichi Nakahira; Jeffrey Adam Haspel; Vijay A K Rathinam; Seon-Jin Lee; Tamas Dolinay; Hilaire C Lam; Joshua A Englert; Marlene Rabinovitch; Manuela Cernadas; Hong Pyo Kim; Katherine A Fitzgerald; Stefan W Ryter; Augustine M K Choi
Journal: Nat Immunol Date: 2010-12-12 Impact factor: 25.606

6. Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1.

Authors: Chengqun Huang; Allen M Andres; Eric P Ratliff; Genaro Hernandez; Pamela Lee; Roberta A Gottlieb
Journal: PLoS One Date: 2011-06-08 Impact factor: 3.240

7. Lipopolysaccharide and tumor necrosis factor regulate Parkin expression via nuclear factor-kappa B.

Authors: Thi A Tran; Andrew D Nguyen; Jianjun Chang; Matthew S Goldberg; Jae-Kyung Lee; Malú G Tansey
Journal: PLoS One Date: 2011-08-17 Impact factor: 3.240

7 in total

10 in total

1. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) phosphorylation by protein kinase Cδ (PKCδ) inhibits mitochondria elimination by lysosomal-like structures following ischemia and reoxygenation-induced injury.

Authors: Gouri Yogalingam; Sunhee Hwang; Julio C B Ferreira; Daria Mochly-Rosen
Journal: J Biol Chem Date: 2013-05-07 Impact factor: 5.157

Review 2. Autophagy, myocardial protection, and the metabolic syndrome.

Authors: Zoltan Giricz; Robert M Mentzer; Roberta A Gottlieb
Journal: J Cardiovasc Pharmacol Date: 2012-08 Impact factor: 3.105

Review 3. Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy.

Authors: Francisco Westermeier; Mario Navarro-Marquez; Camila López-Crisosto; Roberto Bravo-Sagua; Clara Quiroga; Mario Bustamante; Hugo E Verdejo; Ricardo Zalaquett; Mauricio Ibacache; Valentina Parra; Pablo F Castro; Beverly A Rothermel; Joseph A Hill; Sergio Lavandero
Journal: Biochim Biophys Acta Date: 2015-02-14

Impaired mitophagy at the heart of injury.

1. Heart failure in Parkinson's disease: analysis of the United States medicare current beneficiary survey.

2. Stroke and Parkinson's disease.

3. A role for mitochondria in NLRP3 inflammasome activation.

4. PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function.

5. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome.

6. Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1.

7. Lipopolysaccharide and tumor necrosis factor regulate Parkin expression via nuclear factor-kappa B.

1. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) phosphorylation by protein kinase Cδ (PKCδ) inhibits mitochondria elimination by lysosomal-like structures following ischemia and reoxygenation-induced injury.

Review 2. Autophagy, myocardial protection, and the metabolic syndrome.

Review 3. Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy.

Review 4. Myocardial autophagic energy stress responses--macroautophagy, mitophagy, and glycophagy.

5. The zinc transporter ZIP7 (Slc39a7) controls myocardial reperfusion injury by regulating mitophagy.

6. Bicarbonate Increases Ischemia-Reperfusion Damage by Inhibiting Mitophagy.

Review 7. Mitochondrial stress signaling promotes cellular adaptations.

8. Effect of hepatocyte growth factor and angiotensin II on rat cardiomyocyte hypertrophy.

9. HO-1 Protects against Hypoxia/Reoxygenation-Induced Mitochondrial Dysfunction in H9c2 Cardiomyocytes.

Review 10. Cell Death and Inflammation: The Role of Mitochondria in Health and Disease.