Literature DB >> 22082761

The role of microRNAs in human liver cancers.

Chiara Braconi1, Jon C Henry, Takayuki Kogure, Thomas Schmittgen, Tushar Patel.   

Abstract

Hepatocellular carcinoma (HCC) is a primary malignancy of the liver of global importance. Recent studies of the expression and role of microRNA (miRNA) in HCC are providing new insights into disease pathogenesis. In addition, therapeutic efforts targeting specific miRNAs are being evaluated in animal models of HCC. The potential of miRNAs as biomarkers of disease or prognostic markers is being explored. Herein, we review studies of miRNA expression in human HCC, and discuss recent advances in knowledge about the involvement and role of selected miRNAs in disease pathogenesis, as biomarkers, or as therapeutic targets for HCC.
Copyright © 2011. Published by Elsevier Inc.

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Year:  2011        PMID： 22082761      PMCID： PMC3928803          DOI： 10.1053/j.seminoncol.2011.08.001

Source DB:  PubMed          Journal:  Semin Oncol        ISSN： 0093-7754            Impact factor:   4.929


  85 in total

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3.  Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection.

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Authors:  C Coulouarn; V M Factor; J B Andersen; M E Durkin; S S Thorgeirsson
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Journal:  Clin Cancer Res       Date:  2010-01-26       Impact factor: 12.531
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  61 in total

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Journal:  Semin Liver Dis       Date:  2015-01-29       Impact factor: 6.115

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5.  Regulation of proliferation, angiogenesis and apoptosis in hepatocellular carcinoma by miR-26b-5p.

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Review 10.  MicroRNAs in liver disease.

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