AIMS: The biomarkers representing the metastatic potential of well-differentiated thyroid carcinoma remain to be established. A study was undertaken to find whether the expression status of neural cell adhesion molecule (NCAM) and/or ovarian cancer immunoreactive antigen domain containing 1 (OCIAD1) is associated with the metastatic potential of differentiated thyroid carcinoma. METHODS: NCAM and OCIAD1 were analysed by immunohistochemistry on tissue microarrays. RESULTS: Among 214 well-differentiated thyroid carcinomas, 68 patients had distant metastases. Immunohistochemical analyses showed that the majority of benign thyroid lesions expressed NCAM while a significant proportion of thyroid carcinomas lost or had reduced NCAM expression. Both follicular and papillary carcinomas with distant metastasis had a significantly higher frequency of preserving NCAM expression. Hierarchical clustering analysis showed that OCIAD1 had significant differential expression between benign and malignant thyroid lesions. The overall metastatic-to-localised tumour ratio was higher in NCAM-expressing clusters, but the difference between ratios of OCIAD1-positive and OCIAD1-negative subclusters was not significant. CONCLUSIONS: These analyses suggest that the preservation of NCAM expression in well-differentiated thyroid carcinoma is an indicator for a higher risk of distant metastasis. OCIAD1 is a potential biomarker of thyroid carcinoma but had no significant additive effect on the risk of distant metastasis. Further elucidation of the molecular mechanisms underlying the NCAM-mediated cellular processes will be beneficial for the development of effective treatments against the metastasis of thyroid carcinoma.
AIMS: The biomarkers representing the metastatic potential of well-differentiated thyroid carcinoma remain to be established. A study was undertaken to find whether the expression status of neural cell adhesion molecule (NCAM) and/or ovarian cancer immunoreactive antigen domain containing 1 (OCIAD1) is associated with the metastatic potential of differentiated thyroid carcinoma. METHODS:NCAM and OCIAD1 were analysed by immunohistochemistry on tissue microarrays. RESULTS: Among 214 well-differentiated thyroid carcinomas, 68 patients had distant metastases. Immunohistochemical analyses showed that the majority of benign thyroid lesions expressed NCAM while a significant proportion of thyroid carcinomas lost or had reduced NCAM expression. Both follicular and papillary carcinomas with distant metastasis had a significantly higher frequency of preserving NCAM expression. Hierarchical clustering analysis showed that OCIAD1 had significant differential expression between benign and malignant thyroid lesions. The overall metastatic-to-localised tumour ratio was higher in NCAM-expressing clusters, but the difference between ratios of OCIAD1-positive and OCIAD1-negative subclusters was not significant. CONCLUSIONS: These analyses suggest that the preservation of NCAM expression in well-differentiated thyroid carcinoma is an indicator for a higher risk of distant metastasis. OCIAD1 is a potential biomarker of thyroid carcinoma but had no significant additive effect on the risk of distant metastasis. Further elucidation of the molecular mechanisms underlying the NCAM-mediated cellular processes will be beneficial for the development of effective treatments against the metastasis of thyroid carcinoma.
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Authors: S Sowparani; P Mahalakshmi; J Pushpa Sweety; Arul Prakash Francis; U M Dhanalekshmi; N Selvasudha Journal: Mol Neurobiol Date: 2022-07-12 Impact factor: 5.682
Authors: Vincenzo Desiderio; Petros Papagerakis; Virginia Tirino; Li Zheng; Margarite Matossian; Mark E Prince; Francesca Paino; Luigi Mele; Federica Papaccio; Roberta Montella; Gianpaolo Papaccio; Silvana Papagerakis Journal: Oncotarget Date: 2015-01-01
Authors: Tommaso De Marchi; Ning Qing Liu; Cristoph Stingl; Mieke A Timmermans; Marcel Smid; Maxime P Look; Mila Tjoa; Rene B H Braakman; Mark Opdam; Sabine C Linn; Fred C G J Sweep; Paul N Span; Mike Kliffen; Theo M Luider; John A Foekens; John W M Martens; Arzu Umar Journal: Mol Oncol Date: 2015-08-07 Impact factor: 6.603