Literature DB >> 22081748

PTEN-Associated Complexes: An Overview.

Sherly Mosessian1, Hong Wu.   

Abstract

PTEN is a tumor suppressor best characterized for its role as a lipid phosphatase in antagonizing the PI3-kinase pathway. Several recent studies have identified proteins that form high molecular weight complexes with PTEN in different subcellular compartments. PTEN is critical for early embryonic development, cell proliferation, cell survival and stem cell function. The discovery of PTEN complex components may help our understanding of its biological functions. In this review, PTEN complex components, functions and their regulation will be discussed.

Entities:  

Year:  2010        PMID： 22081748      PMCID： PMC3212753     

Source DB:  PubMed          Journal:  Curr Top Biochem Res        ISSN： 0972-4583


  39 in total

1.  Phosphorylation of the PTEN tail regulates protein stability and function.

Authors:  F Vazquez; S Ramaswamy; N Nakamura; W R Sellers
Journal:  Mol Cell Biol       Date:  2000-07       Impact factor: 4.272

2.  The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation.

Authors:  J Torres; R Pulido
Journal:  J Biol Chem       Date:  2001-01-12       Impact factor: 5.157

3.  Electrostatic control of the membrane targeting of C2 domains.

Authors:  Diana Murray; Barry Honig
Journal:  Mol Cell       Date:  2002-01       Impact factor: 17.970

4.  Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane.

Authors:  Francisca Vazquez; Satomi Matsuoka; William R Sellers; Toshio Yanagida; Masahiro Ueda; Peter N Devreotes
Journal:  Proc Natl Acad Sci U S A       Date:  2006-02-28       Impact factor: 11.205

Review 5.  PTEN function in normal and neoplastic growth.

Authors:  Lionel M L Chow; Suzanne J Baker
Journal:  Cancer Lett       Date:  2006-01-18       Impact factor: 8.679

Review 6.  PIKE/nuclear PI 3-kinase signaling in preventing programmed cell death.

Authors:  Keqiang Ye
Journal:  J Cell Biochem       Date:  2005-10-15       Impact factor: 4.429

7.  PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms.

Authors:  Daniel J Freeman; Andrew G Li; Gang Wei; Heng-Hong Li; Nathalie Kertesz; Ralf Lesche; Andrew D Whale; Hilda Martinez-Diaz; Nora Rozengurt; Robert D Cardiff; Xuan Liu; Hong Wu
Journal:  Cancer Cell       Date:  2003-02       Impact factor: 31.743

8.  A novel genetic system to detect protein-protein interactions.

Authors:  S Fields; O Song
Journal:  Nature       Date:  1989-07-20       Impact factor: 49.962

Review 9.  PTEN signaling in brain: neuropathology and tumorigenesis.

Authors:  R Endersby; S J Baker
Journal:  Oncogene       Date:  2008-09-18       Impact factor: 9.867

10.  Synergy in tumor suppression by direct interaction of neutral endopeptidase with PTEN.

Authors:  Makoto Sumitomo; Akira Iwase; Rong Zheng; Daniel Navarro; David Kaminetzky; Ruoqian Shen; Maria-Magdalena Georgescu; David M Nanus
Journal:  Cancer Cell       Date:  2004-01       Impact factor: 31.743
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  1 in total

1.  PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha.

Authors:  Chunhua Yang; Shujing Li; Miao Wang; Alan K Chang; Ying Liu; Feng Zhao; Liyun Xiao; Lin Han; Dao Wang; Shen Li; Huijian Wu
Journal:  Mol Cancer       Date:  2013-03-21       Impact factor: 27.401
  1 in total

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