D D Zheng1, Z H Liu, J Fang, X Y Wang, J Zhang. 1. Academy of Advanced Interdisciplinary Studies, Peking University, Beijing, China, People's Republic of China.
Abstract
BACKGROUND AND PURPOSE: DW-MRS is a promising tool for the noninvasive identification of the cellular response to cerebral ischemia. To date, the potential confounding effects of aging and the stage of ischemia are unknown. We, therefore, examined the cross-sectional effects of age and different stages of cerebral ischemia on the diffusion of brain metabolites. MATERIALS AND METHODS: The ADCs of 3 major metabolites, including Cho, Cr, and NAA were measured by DW-MRS in healthy younger (n = 26, 24 ± 2.2 years of age) and older (n = 17, 63 ± 7.0 years of age) adults, as well as in patients with acute (n = 7, 57 ± 4.0 years of age) and subacute (n = 12, 62 ± 7.8 years of age) cerebral ischemia. RESULTS: Compared with younger adults, healthy older adults presented with significantly reduced ADC values of NAA (P = .000052), Cr (P = .000018), and Cho (P = .00075). Meanwhile, the ADC values of NAA (F(2,36) = 6.057, P = .006), Cr (F(2,36) = 5.634, P = .008), and Cho (F(2,36) = 8.167, P = .001) were significantly different among the acute cerebral ischemia group, subacute cerebral ischemia group, and healthy older controls. These metabolites decreased in the acute stage of cerebral ischemia but increased in the subacute stage, compared with age-matched controls. CONCLUSIONS: The effect of age should be considered when analyzing diffusion of cerebral metabolites with DW-MRS. Our observations also suggest that metabolite diffusion data may be used to reveal changes in the intracellular environment, depending on the pathologic status of ischemia.
BACKGROUND AND PURPOSE: DW-MRS is a promising tool for the noninvasive identification of the cellular response to cerebral ischemia. To date, the potential confounding effects of aging and the stage of ischemia are unknown. We, therefore, examined the cross-sectional effects of age and different stages of cerebral ischemia on the diffusion of brain metabolites. MATERIALS AND METHODS: The ADCs of 3 major metabolites, including Cho, Cr, and NAA were measured by DW-MRS in healthy younger (n = 26, 24 ± 2.2 years of age) and older (n = 17, 63 ± 7.0 years of age) adults, as well as in patients with acute (n = 7, 57 ± 4.0 years of age) and subacute (n = 12, 62 ± 7.8 years of age) cerebral ischemia. RESULTS: Compared with younger adults, healthy older adults presented with significantly reduced ADC values of NAA (P = .000052), Cr (P = .000018), and Cho (P = .00075). Meanwhile, the ADC values of NAA (F(2,36) = 6.057, P = .006), Cr (F(2,36) = 5.634, P = .008), and Cho (F(2,36) = 8.167, P = .001) were significantly different among the acute cerebral ischemia group, subacute cerebral ischemia group, and healthy older controls. These metabolites decreased in the acute stage of cerebral ischemia but increased in the subacute stage, compared with age-matched controls. CONCLUSIONS: The effect of age should be considered when analyzing diffusion of cerebral metabolites with DW-MRS. Our observations also suggest that metabolite diffusion data may be used to reveal changes in the intracellular environment, depending on the pathologic status of ischemia.
Authors: Fuhai Li; Kai-Feng Liu; Matthew D Silva; Xiangjun Meng; Tibo Gerriets; Karl G Helmer; Joseph D Fenstermacher; Christopher H Sotak; Marc Fisher Journal: AJNR Am J Neuroradiol Date: 2002-02 Impact factor: 3.825
Authors: Ece Ercan; Cesar Magro-Checa; Romain Valabregue; Francesca Branzoli; Emily T Wood; Gerda M Steup-Beekman; Andrew G Webb; Tom W J Huizinga; Mark A van Buchem; Itamar Ronen Journal: Brain Date: 2016-03-11 Impact factor: 13.501