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Literature DB >> 22081093

A new cap for kinetochore fibre minus ends.

Abstract

In mitotic spindles, each sister chromatid is directly attached to a spindle pole through microtubule bundles known as kinetochore fibres. Microspherule protein 1 (MCRS1) is now shown to support spindle assembly by localizing to the minus ends of kinetochore fibres and protecting them from depolymerization.

Entities: Chemical

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Year: 2011 PMID： 22081093 PMCID： PMC3532025 DOI： 10.1038/ncb2387

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

15 in total

1. Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity.

Authors: O J Gruss; R E Carazo-Salas; C A Schatz; G Guarguaglini; J Kast; M Wilm; N Le Bot; I Vernos; E Karsenti; I W Mattaj
Journal: Cell Date: 2001-01-12 Impact factor: 41.582

2. K-fibre minus ends are stabilized by a RanGTP-dependent mechanism essential for functional spindle assembly.

Authors: Sylvain Meunier; Isabelle Vernos
Journal: Nat Cell Biol Date: 2011-11-13 Impact factor: 28.824

Review 3. Mechanisms of mitotic spindle assembly and function.

Authors: Claire E Walczak; Rebecca Heald
Journal: Int Rev Cytol Date: 2008

4. The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work.

Authors: J C Waters; T J Mitchison; C L Rieder; E D Salmon
Journal: Mol Biol Cell Date: 1996-10 Impact factor: 4.138

5. Drosophila MCRS2 associates with RNA polymerase II complexes to regulate transcription.

Authors: Ditte Skovaa Andersen; Sunil Jayaramaiah Raja; Julien Colombani; Rachael Louise Shaw; Paul Francis Langton; Asifa Akhtar; Nicolas Tapon
Journal: Mol Cell Biol Date: 2010-08-02 Impact factor: 4.272

6. Microspherule protein 1, Mi-2beta, and RET finger protein associate in the nucleolus and up-regulate ribosomal gene transcription.

Authors: Keiko Shimono; Yohei Shimono; Kaoru Shimokata; Naoki Ishiguro; Masahide Takahashi
Journal: J Biol Chem Date: 2005-09-26 Impact factor: 5.157

A new cap for kinetochore fibre minus ends.

1. Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity.

2. K-fibre minus ends are stabilized by a RanGTP-dependent mechanism essential for functional spindle assembly.

Review 3. Mechanisms of mitotic spindle assembly and function.

4. The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work.

5. Drosophila MCRS2 associates with RNA polymerase II complexes to regulate transcription.

6. Microspherule protein 1, Mi-2beta, and RET finger protein associate in the nucleolus and up-regulate ribosomal gene transcription.

7. Kinetochore microtubule dynamics and attachment stability are regulated by Hec1.

8. p78/MCRS1 forms a complex with centrosomal protein Nde1 and is essential for cell viability.

9. Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length.

10. Patronin regulates the microtubule network by protecting microtubule minus ends.

Review 1. Nuclear transport factors: global regulation of mitosis.