| Literature DB >> 22080372 |
Su Na Kim1, Hyun Pyo Shim, Bu-Nam Jeon, Won-Il Choi, Man-Wook Hur, Jack R Girton, Sang Hee Kim, Sang-Hak Jeon.
Abstract
Polycomb group (PcG) proteins maintain the spatial expression patterns of genes that are involved in cell-fate specification along the anterior-posterior (A/P) axis. This repression requires cis-acting silencers, which are called PcG response elements (PREs). One of the PcG proteins, Pleiohomeotic (Pho), which has a zinc finger DNA binding protein, plays a critical role in recruiting other PcG proteins to bind to PREs. In this study, we characterized the effects of a pho mutation on embryonic segmentation. pho maternal mutant embryos showed various segmental defects including pair-rule gene mutant patterns. Our results indicated that engrailed and even-skipped genes were misexpressed in pho mutant embryos, which caused embryonic segment defects.Entities:
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Year: 2011 PMID： 22080372 PMCID： PMC3887676 DOI： 10.1007/s10059-011-0173-9
Source DB: PubMed Journal: Mol Cells ISSN： 1016-8478 Impact factor: 5.034