Literature DB >> 22079740

Sleeping beauty--a mouse model for all cancers?

Viive M Howell1.   

Abstract

Sleeping Beauty (SB) is a genetically engineered insertional mutagenesis system. Its ability to rapidly induce cancer in SB-transgenic mice as well as the ease of identification of the mutated genes suggest important roles for SB in the discovery of novel cancer genes as well as the generation of models of human cancers where none currently exist. The range of SB-related tumors extends from haematopoietic to solid cancers such as hepatocellular carcinoma. This review follows the refinement of SB for different cancers and assesses its potential as a model for all cancers and a tool for cancer gene discovery.
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

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Year:  2011        PMID： 22079740     DOI： 10.1016/j.canlet.2011.11.006

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  10 in total

1.  Transposon mutagenesis identifies chromatin modifiers cooperating with Ras in thyroid tumorigenesis and detects ATXN7 as a cancer gene.

Authors:  Cristina Montero-Conde; Luis J Leandro-Garcia; Xu Chen; Gisele Oler; Sergio Ruiz-Llorente; Mabel Ryder; Iñigo Landa; Francisco Sanchez-Vega; Konnor La; Ronald A Ghossein; Dean F Bajorin; Jeffrey A Knauf; Jesse D Riordan; Adam J Dupuy; James A Fagin
Journal:  Proc Natl Acad Sci U S A       Date:  2017-06-05       Impact factor: 11.205

Review 2.  Mouse models of cancer: Sleeping Beauty transposons for insertional mutagenesis screens and reverse genetic studies.

Authors:  Barbara R Tschida; David A Largaespada; Vincent W Keng
Journal:  Semin Cell Dev Biol       Date:  2014-01-24       Impact factor: 7.727

3.  Electroporation markedly improves Sleeping Beauty transposon-induced tumorigenesis in mice.

Authors:  S Jung; H-J Choi; H-K Park; W Jo; S Jang; J-E Ryu; W-J Kim; E-S Yu; W-C Son
Journal:  Cancer Gene Ther       Date:  2014-07-04       Impact factor: 5.987

Review 4.  Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy.

Authors:  Perry B Hackett; David A Largaespada; Kirsten C Switzer; Laurence J N Cooper
Journal:  Transl Res       Date:  2013-01-10       Impact factor: 7.012

Review 5.  Malignant peripheral nerve sheath tumors.

Authors:  Mohamad Farid; Elizabeth G Demicco; Roberto Garcia; Linda Ahn; Pamela R Merola; Angela Cioffi; Robert G Maki
Journal:  Oncologist       Date:  2014-01-27

6.  Sequencing methods and datasets to improve functional interpretation of sleeping beauty mutagenesis screens.

Authors:  Jesse D Riordan; Luke J Drury; Ryan P Smith; Benjamin T Brett; Laura M Rogers; Todd E Scheetz; Adam J Dupuy
Journal:  BMC Genomics       Date:  2014-12-19       Impact factor: 3.969

7.  Simple and efficient methods for enrichment and isolation of endonuclease modified cells.

Authors:  Branden S Moriarity; Eric P Rahrmann; Dominic A Beckmann; Caitlin B Conboy; Adrienne L Watson; Daniel F Carlson; Erik R Olson; Kendra A Hyland; Scott C Fahrenkrug; R Scott McIvor; David A Largaespada
Journal:  PLoS One       Date:  2014-05-05       Impact factor: 3.240

8.  Development of a Mouse Model of Prostate Cancer Using the Sleeping Beauty Transposon and Electroporation.

Authors:  Hyun-Ji Choi; Han-Byul Lee; Sunyoung Jung; Hyun-Kyu Park; Woori Jo; Sung-Min Cho; Woo-Jin Kim; Woo-Chan Son
Journal:  Molecules       Date:  2018-06-05       Impact factor: 4.411

9.  Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis.

Authors:  Jesse D Riordan; Vincent W Keng; Barbara R Tschida; Todd E Scheetz; Jason B Bell; Kelly M Podetz-Pedersen; Catherine D Moser; Neal G Copeland; Nancy A Jenkins; Lewis R Roberts; David A Largaespada; Adam J Dupuy
Journal:  PLoS Genet       Date:  2013-04-04       Impact factor: 5.917

10.  Sleeping Beauty transposon system harboring HRAS, c-Myc and shp53 induces sarcomatoid carcinomas in mouse skin.

Authors:  Sunyoung Jung; Simon Weonsang Ro; Geunyoung Jung; Hye-Lim Ju; Eun-Sil Yu; Woo-Chan Son
Journal:  Oncol Rep       Date:  2013-01-31       Impact factor: 3.906
  10 in total

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