Robinson Ramírez-Vélez1. 1. School of Medicine, University of Valle, Cali, Colombia. robin640@hotmail.com
Abstract
OBJECTIVE: To assess the effect of postprandial lipemia on endothelial function, insulin resistance, and lipid profile in healthy subjects. PATIENTS AND METHODS: A prospective', interventional study in 14 healthy young men aged 18-25 years who were given a high-fat meal. Endothelial function was measured using flow-mediated dilation (FMD) in the brachial artery, flow velocity, mean arterial pressure and serum nitrite/nitrate levels (NO(2)/NO(3)). Glucose, insulin, total cholesterol, and triglyceride levels were also tested. Insulin resistance was determined by calculating the HOMA-IR index (Homeostatic Model Assessment-Insulin Resistance). RESULTS: Baseline FMD was 5.9 ± 1.1%. Postprandial lipemia reduced endothelial function by approximately 50% in the first (3.3 ± 0.5%, p=0.03) and second (3.3 ± 0.4%, p=0.04) moment respectively. This finding was associated to an increased flow rate in the brachial artery and lower NO(2)/NO(3) levels (p<0.05). Higher cholesterol and triglyceride levels were found 1h and 2h postprandial (p<0.05). HOMA-IR was significantly increased 1h and 2h postprandial (p<0.05). CONCLUSIONS: Postprandial lipemia causes changes in circulating lipid profile and induces endothelial dysfunction and higher insulin resistance.
OBJECTIVE: To assess the effect of postprandial lipemia on endothelial function, insulin resistance, and lipid profile in healthy subjects. PATIENTS AND METHODS: A prospective', interventional study in 14 healthy young men aged 18-25 years who were given a high-fat meal. Endothelial function was measured using flow-mediated dilation (FMD) in the brachial artery, flow velocity, mean arterial pressure and serum nitrite/nitrate levels (NO(2)/NO(3)). Glucose, insulin, total cholesterol, and triglyceride levels were also tested. Insulin resistance was determined by calculating the HOMA-IR index (Homeostatic Model Assessment-Insulin Resistance). RESULTS: Baseline FMD was 5.9 ± 1.1%. Postprandial lipemia reduced endothelial function by approximately 50% in the first (3.3 ± 0.5%, p=0.03) and second (3.3 ± 0.4%, p=0.04) moment respectively. This finding was associated to an increased flow rate in the brachial artery and lower NO(2)/NO(3) levels (p<0.05). Higher cholesterol and triglyceride levels were found 1h and 2h postprandial (p<0.05). HOMA-IR was significantly increased 1h and 2h postprandial (p<0.05). CONCLUSIONS: Postprandial lipemia causes changes in circulating lipid profile and induces endothelial dysfunction and higher insulin resistance.
Authors: Lorisa S Teixeira; Arleilson S Lima; Ana Paula A Boleti; Adley A N Lima; Said T Libório; Lucia de Paula; Maria Inês B Oliveira; Everton F Lima; Geison M Costa; Flávio H Reginatto; Emerson S Lima Journal: J Nat Med Date: 2014-04 Impact factor: 2.343
Authors: Gustavo S M Araujo; Thiago O C Silva; Grazia M Guerra; João E Izaias; Helena M N Rocha; Diego Faria; Natalia G Rocha; Aline Lopes Dalmazo; Amanda Araujo; Fernanda Marciano Consolim-Colombo; Katia de Angelis; Maria C C Irigoyen; Allan R K Sales Journal: Front Physiol Date: 2022-02-24 Impact factor: 4.566
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