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Literature DB >> 22076163

Role of leptin and its receptors in the pathogenesis of thyroid cancer.

Shahab Uddin¹, Azhar R Hussain, Abdul K Siraj, Omar S Khan, Prashant P Bavi, Khawla S Al-Kuraya.

Abstract

Leptin is a multifunctional adipose-derived cytokines that play a critical role in bodyweight homeostasis and energy balance. Recently, leptin and leptin receptor dysreulation have been reported in variety of malignant cells including thyroid. Leptin modulates growth and proliferation of cancer cells via activation of various growth and survival signaling pathways including JAK/STAT, PI3-kinase/AKT and/or Map kinases. In this review, current understanding of leptin's role in the pathogenesis of thyroid cancer has been described.

Entities: Chemical

Keywords: Leptin; leptin receptors; papillary thyroid carcinoma; sinaling pathways

Mesh：

Substances：

Year: 2011 PMID： 22076163 PMCID： PMC3209603

Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN： 1936-2625

54 in total

1. Leptin receptor expression and its association with PI3K/AKT signaling pathway in diffuse large B-cell lymphoma.

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Journal: Leuk Lymphoma Date: 2010-07

Review 2. The Akt-mTOR tango and its relevance to cancer.

Authors: Nissim Hay
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Review 3. Stress-responsive protein kinases in redox-regulated apoptosis signaling.

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4. Regulation of phosphatidylinositol 3'-kinase by tyrosyl phosphoproteins. Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit.

Authors: T Rordorf-Nikolic; D J Van Horn; D Chen; M F White; J M Backer
Journal: J Biol Chem Date: 1995-02-24 Impact factor: 5.157

5. Leptin expression correlates with favorable clinicopathologic phenotype and better prognosis in colorectal adenocarcinoma.

Authors: Seung Sam Paik; Se-Min Jang; Ki-Seok Jang; Kang Hong Lee; Dongho Choi; Se Jin Jang
Journal: Ann Surg Oncol Date: 2008-12-03 Impact factor: 5.344

6. Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal-transduction pathways.

Authors: Tamara Jaffe; Betty Schwartz
Journal: Int J Cancer Date: 2008-12-01 Impact factor: 7.396

7. Clinicopathologic significance of leptin and leptin receptor expressions in papillary thyroid carcinoma.

Authors: Shih-Ping Cheng; Chin-Wen Chi; Chi-Yuan Tzen; Tsen-Long Yang; Jie-Jen Lee; Tsang-Pai Liu; Chien-Liang Liu
Journal: Surgery Date: 2009-12-31 Impact factor: 3.982

8. Leptin receptor expression in Middle Eastern colorectal cancer and its potential clinical implication.

Authors: Shahab Uddin; Prashant P Bavi; Azhar R Hussain; Ghazi Alsbeih; Nasser Al-Sanea; Alaa Abduljabbar; Luai H Ashari; Samar Alhomoud; Fouad Al-Dayel; Maqbool Ahmed; Khawla S Al-Kuraya
Journal: Carcinogenesis Date: 2009-06-11 Impact factor: 4.944

9. Leptin secretion and leptin receptor in the human stomach.

Authors: I Sobhani; A Bado; C Vissuzaine; M Buyse; S Kermorgant; J P Laigneau; S Attoub; T Lehy; D Henin; M Mignon; M J Lewin
Journal: Gut Date: 2000-08 Impact factor: 23.059

10. High rate of persistent/recurrent disease among patients with differentiated thyroid cancer in Saudi Arabia: factors affecting nonremission.

Authors: Hussain Raef; Eman Alfadhli; Alya Al-Hajjaj; Usman H Malabu; Saif Al-Sobhi; Ayman Rifai; Abdulrahman Al Nuaim
Journal: Ann Saudi Med Date: 2008 Jul-Aug Impact factor: 1.526

11 in total

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Journal: Dig Dis Sci Date: 2016-02-26 Impact factor: 3.199

Review 3. Review of Factors Contributing to Nodular Goiter and Thyroid Carcinoma.

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4. Postnatal leptin promotes organ maturation and development in IUGR piglets.

Authors: Linda Attig; Daphné Brisard; Thibaut Larcher; Michal Mickiewicz; Paul Guilloteau; Samir Boukthir; Claude-Narcisse Niamba; Arieh Gertler; Jean Djiane; Danielle Monniaux; Latifa Abdennebi-Najar
Journal: PLoS One Date: 2013-05-31 Impact factor: 3.240

Review 5. Insulin Resistance: Any Role in the Changing Epidemiology of Thyroid Cancer?

Authors: Roberta Malaguarnera; Veronica Vella; Maria Luisa Nicolosi; Antonino Belfiore
Journal: Front Endocrinol (Lausanne) Date: 2017-11-14 Impact factor: 5.555

6. Expression of Leptin Receptor and Effects of Leptin on Papillary Thyroid Carcinoma Cells.

Authors: Marilena Celano; Valentina Maggisano; Saverio Massimo Lepore; Marialuisa Sponziello; Valeria Pecce; Antonella Verrienti; Cosimo Durante; Marianna Maranghi; Piernatale Lucia; Stefania Bulotta; Giuseppe Damante; Diego Russo
Journal: Int J Endocrinol Date: 2019-02-14 Impact factor: 3.257

Review 7. Adipocytokines in thyroid dysfunction.

Authors: Berna İmge Aydogan; Mustafa Sahin
Journal: ISRN Inflamm Date: 2013-06-23

8. Diagnostic value of ultrasound features and sex of fetuses in female patients with papillary thyroid microcarcinoma.

Authors: Chun-Jie Hou; Ran Wei; Jing-Lan Tang; Qiao-Hong Hu; Hong-Feng He; Xiao-Ming Fan
Journal: Sci Rep Date: 2018-05-14 Impact factor: 4.379

9. An 18-year study of thyroid carcinoma in the western region of Saudi Arabia: a retrospective single-center study in a community hospital.

Authors: Khalid S Aljabri; Samia A Bokhari; Muneera A Al; Patan Murthuza Khan
Journal: Ann Saudi Med Date: 2018 Sep-Oct Impact factor: 1.526

10. The Expression of Leptin and Its Receptor During Tumorigenesis of Diffuse Gliomas such as Astrocytoma and Oligodendroglioma- Grade II, III and IV (NOS)

Authors: Ramya S Vokuda; Srinivas B H; Venkastesh S Madhugiri; Saravana Kumar Velusamy; Surendra Kumar Verma
Journal: Asian Pac J Cancer Prev Date: 2019-02-26