AIM: It remains uncertain whether chronic exposure to particulate air pollution is associated with increased mortality in Japan because Japan has a different distribution pattern of cardiovascular disease and its risk factors compared to Western countries. We investigated the association between long-term exposure to particulate matter (PM) and cardiovascular mortality risk using a representative Japanese cohort. METHODS: A total of 7,250 participants aged 30 years and older from 232 districts throughout Japan were followed from 1980 to 2004. We linked the averaged annual concentrations of PM from 1985 to 2004 to each cohort participant who resided in the district at the time of the baseline survey. Study participants were divided into quintiles of average PM concentration. We applied the Cox proportional hazard model adjusting for sex, age, body mass index, blood pressure, total cholesterol, blood glucose, smoking categories, drinking categories, and the municipality population size. RESULTS: During follow-up, there were 1,716 deaths from all causes; 571 from cardiovascular disease, 116 from coronary heart disease, and 250 from stroke. Hazard ratios were not different among the quintiles and those for trend per 10 µg/m3 increase in annual PM concentration were 0.98 (95% confidence interval, 0.92-1.04) for all-cause mortality and 0.90 (95% confidence interval, 0.81-1.00) for cardiovascular mortality. CONCLUSION: Long-term exposure to PM was not associated with increased cardiovascular mortality risk in this population-based cohort in Japan.
RCT Entities:
AIM: It remains uncertain whether chronic exposure to particulate air pollution is associated with increased mortality in Japan because Japan has a different distribution pattern of cardiovascular disease and its risk factors compared to Western countries. We investigated the association between long-term exposure to particulate matter (PM) and cardiovascular mortality risk using a representative Japanese cohort. METHODS: A total of 7,250 participants aged 30 years and older from 232 districts throughout Japan were followed from 1980 to 2004. We linked the averaged annual concentrations of PM from 1985 to 2004 to each cohort participant who resided in the district at the time of the baseline survey. Study participants were divided into quintiles of average PM concentration. We applied the Cox proportional hazard model adjusting for sex, age, body mass index, blood pressure, total cholesterol, blood glucose, smoking categories, drinking categories, and the municipality population size. RESULTS: During follow-up, there were 1,716 deaths from all causes; 571 from cardiovascular disease, 116 from coronary heart disease, and 250 from stroke. Hazard ratios were not different among the quintiles and those for trend per 10 µg/m3 increase in annual PM concentration were 0.98 (95% confidence interval, 0.92-1.04) for all-cause mortality and 0.90 (95% confidence interval, 0.81-1.00) for cardiovascular mortality. CONCLUSION: Long-term exposure to PM was not associated with increased cardiovascular mortality risk in this population-based cohort in Japan.
Authors: Hakim-Moulay Dehbi; Marta Blangiardo; John Gulliver; Daniela Fecht; Kees de Hoogh; Zaina Al-Kanaani; Therese Tillin; Rebecca Hardy; Nish Chaturvedi; Anna L Hansell Journal: Environ Int Date: 2016-12-07 Impact factor: 9.621
Authors: Gerard Hoek; Ranjini M Krishnan; Rob Beelen; Annette Peters; Bart Ostro; Bert Brunekreef; Joel D Kaufman Journal: Environ Health Date: 2013-05-28 Impact factor: 5.984
Authors: Chit Ming Wong; Hak Kan Lai; Hilda Tsang; Thuan Quoc Thach; G Neil Thomas; Kin Bong Hubert Lam; King Pan Chan; Lin Yang; Alexis K H Lau; Jon G Ayres; Siu Yin Lee; Wai Man Chan; Anthony J Hedley; Tai Hing Lam Journal: Environ Health Perspect Date: 2015-04-24 Impact factor: 9.031
Authors: Kihal-Talantikite Wahida; Cindy M Padilla; Zmirou-Navier Denis; Blanchard Olivier; Le Nir Géraldine; Quenel Philippe; Deguen Séverine Journal: Int J Environ Res Public Health Date: 2016-03-15 Impact factor: 3.390