Literature DB >> 22074807

No association of ALOX5AP polymorphisms with risk of MRI-defined brain infarcts.

Sandra Barral1, Israel Fernández-Cadenas, Joshua C Bis, Joan Montaner, Arfan M Ikram, Lenore J Launer, Myriam Fornage, Helena Schmidt, Adam M Brickman, Sudha Seshadri, Richard Mayeux.   

Abstract

The arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene has been associated with stroke. The majority of the reported ALOX5AP associations have considered non-radiologically confirmed infarcts as the stroke phenotype. We assessed the association of genetic variants in ALOX5AP with stroke defined by the presence of infarcts on brain magnetic resonance imaging (MRI). We studied 202 persons with MRI-defined brain infarcts and 487 healthy individuals of Caribbean Hispanic ancestry. Another sample of European ancestry comprised 1823 persons with MRI-defined brain infarct and 7578 control subjects. Subjects were genotyped for the 4 single nucleotide polymorphisms (SNPs) that define ALOX5AP HapA haplotype. No association was found between SNPs and MRI-defined brain infarcts. Our data do not support the hypothesis that variants in ALOX5AP are associated with risk of MRI-defined brain infarcts.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 22074807      PMCID： PMC3259245          DOI： 10.1016/j.neurobiolaging.2011.10.010

Source DB:  PubMed          Journal:  Neurobiol Aging        ISSN： 0197-4580            Impact factor:   4.673


  8 in total

1.  Sample size requirements for matched case-control studies of gene-environment interaction.

Authors:  W James Gauderman
Journal:  Stat Med       Date:  2002-01-15       Impact factor: 2.373

2.  Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits.

Authors:  S Purcell; S S Cherny; P C Sham
Journal:  Bioinformatics       Date:  2003-01       Impact factor: 6.937

3.  Brain morphology in older African Americans, Caribbean Hispanics, and whites from northern Manhattan.

Authors:  Adam M Brickman; Nicole Schupf; Jennifer J Manly; José A Luchsinger; Howard Andrews; Ming X Tang; Christiane Reitz; Scott A Small; Richard Mayeux; Charles DeCarli; Truman R Brown
Journal:  Arch Neurol       Date:  2008-08

4.  Genetic variants of arachidonate 5-lipoxygenase-activating protein, and risk of incident myocardial infarction and ischemic stroke: a nested case-control approach.

Authors:  Robert Y L Zee; Suzanne Cheng; Hillary H Hegener; Henry A Erlich; Paul M Ridker
Journal:  Stroke       Date:  2006-06-15       Impact factor: 7.914

5.  The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke.

Authors:  Anna Helgadottir; Andrei Manolescu; Gudmar Thorleifsson; Solveig Gretarsdottir; Helga Jonsdottir; Unnur Thorsteinsdottir; Nilesh J Samani; Gudmundur Gudmundsson; Struan F A Grant; Gudmundur Thorgeirsson; Sigurlaug Sveinbjornsdottir; Einar M Valdimarsson; Stefan E Matthiasson; Halldor Johannsson; Olof Gudmundsdottir; Mark E Gurney; Jesus Sainz; Margret Thorhallsdottir; Margret Andresdottir; Michael L Frigge; Eric J Topol; Augustine Kong; Vilmundur Gudnason; Hakon Hakonarson; Jeffrey R Gulcher; Kari Stefansson
Journal:  Nat Genet       Date:  2004-02-08       Impact factor: 38.330

6.  Validity of self-reported stroke in elderly African Americans, Caribbean Hispanics, and Whites.

Authors:  Christiane Reitz; Nicole Schupf; José A Luchsinger; Adam M Brickman; Jennifer J Manly; Howard Andrews; Ming X Tang; Charles DeCarli; Truman R Brown; Richard Mayeux
Journal:  Arch Neurol       Date:  2009-05-11

7.  Phosphodiesterase 4D and 5-lipoxygenase activating protein genes and risk of ischemic stroke in Sardinians.

Authors:  Giovanni Quarta; Rosita Stanzione; Anna Evangelista; Bastianina Zanda; Emanuele Di Angelantonio; Simona Marchitti; Sara Di Castro; Marta Di Vavo; Massimo Volpe; Speranza Rubattu
Journal:  Eur J Hum Genet       Date:  2009-05-06       Impact factor: 4.246

8.  Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium.

Authors:  Stéphanie Debette; Joshua C Bis; Myriam Fornage; Helena Schmidt; M Arfan Ikram; Sigurdur Sigurdsson; Gerardo Heiss; Maksim Struchalin; Albert V Smith; Aad van der Lugt; Charles DeCarli; Thomas Lumley; David S Knopman; Christian Enzinger; Gudny Eiriksdottir; Peter J Koudstaal; Anita L DeStefano; Bruce M Psaty; Carole Dufouil; Diane J Catellier; Franz Fazekas; Thor Aspelund; Yurii S Aulchenko; Alexa Beiser; Jerome I Rotter; Christophe Tzourio; Dean K Shibata; Maria Tscherner; Tamara B Harris; Fernando Rivadeneira; Larry D Atwood; Kenneth Rice; Rebecca F Gottesman; Mark A van Buchem; Andre G Uitterlinden; Margaret Kelly-Hayes; Mary Cushman; Yicheng Zhu; Eric Boerwinkle; Vilmundur Gudnason; Albert Hofman; Jose R Romero; Oscar Lopez; Cornelia M van Duijn; Rhoda Au; Susan R Heckbert; Philip A Wolf; Thomas H Mosley; Sudha Seshadri; Monique M B Breteler; Reinhold Schmidt; Lenore J Launer; W T Longstreth
Journal:  Stroke       Date:  2009-12-31       Impact factor: 7.914
  8 in total
  4 in total

1.  A novel risk haplotype of ALOX5AP gene is associated with ischemic stroke in Chinese Han population.

Authors:  Dongzhi Yang; Ying He; Manyu Li; Congcong Shi; Guoying Song; Qing Wang; Yujia Fan; Qingchuan Feng; Hong Zheng
Journal:  J Mol Neurosci       Date:  2013-11-07       Impact factor: 3.444

2.  The SG13S114 polymorphism of the ALOX5AP gene is associated with ischemic stroke in Europeans: a meta-analysis of 8062 subjects.

Authors:  Zhongjun Chen; Jinyu Zheng; Wenguang Liu; Kun Yang; Kai Li; Baosheng Huang; Ronglan Zhu; Xiaocheng Lu; Lixin Li
Journal:  Neurol Sci       Date:  2017-01-18       Impact factor: 3.307

Review 3.  Mammalian lipoxygenases and their biological relevance.

Authors:  Hartmut Kuhn; Swathi Banthiya; Klaus van Leyen
Journal:  Biochim Biophys Acta       Date:  2014-10-12

Review 4.  Lipoxygenase: an emerging target for stroke therapy.

Authors:  Klaus van Leyen
Journal:  CNS Neurol Disord Drug Targets       Date:  2013-03       Impact factor: 4.388
  4 in total

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