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Literature DB >> 2207266

IK inactivation in squid axons is shifted along the voltage axis by changes in the intracellular pH.

Abstract

The inactivation curve of the delayed rectifier in internally perfused squid giant axons is shifted along the voltage axis by changes in the pH of the internal perfusate. The amplitude of the shift is 9.5 mV per pH unit (6 less than or equal to pHi less than or equal to 10). No saturation of the effect was observed at either end of the pH range. This result suggests that the inactivation gating mechanism has several titratable groups accessible to protons from the intracellular side of the membrane.

Mesh：

Substances：
Potassium

Year: 1990 PMID： 2207266 PMCID： PMC1281021 DOI： 10.1016/S0006-3495(90)82423-1

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

16 in total

1. Effects of the external pH on Ca channels: experimental studies and theoretical considerations using a two-site, two-ion model.

Authors: T Iijima; S Ciani; S Hagiwara
Journal: Proc Natl Acad Sci U S A Date: 1986-02 Impact factor: 11.205

2. Charges and potentials at the nerve surface. Divalent ions and pH.

Authors: B Hille
Journal: J Gen Physiol Date: 1968-02 Impact factor: 4.086

3. The kinetics of recovery and development of potassium channel inactivation in perfused squid (Loligo pealei) giant axons.

Authors: L D Chabala
Journal: J Physiol Date: 1984-11 Impact factor: 5.182

4. K+ conductance modified by a titratable group accessible to protons from the intracellular side of the squid axon membrane.

Authors: E Wanke; E Carbone; P L Testa
Journal: Biophys J Date: 1979-05 Impact factor: 4.033

Review 5. Intracellular pH.

Authors: A Roos; W F Boron
Journal: Physiol Rev Date: 1981-04 Impact factor: 37.312

IK inactivation in squid axons is shifted along the voltage axis by changes in the intracellular pH.

1. Effects of the external pH on Ca channels: experimental studies and theoretical considerations using a two-site, two-ion model.

2. Charges and potentials at the nerve surface. Divalent ions and pH.

3. The kinetics of recovery and development of potassium channel inactivation in perfused squid (Loligo pealei) giant axons.

4. K+ conductance modified by a titratable group accessible to protons from the intracellular side of the squid axon membrane.

Review 5. Intracellular pH.

6. Slow changes of potassium permeability in the squid giant axon.

7. Potassium channel kinetics in squid axons with elevated levels of external potassium concentration.

8. Effects of external cesium and rubidium on outward potassium currents in squid axons.

9. Ionic conductance changes in voltage clamped crayfish axons at low pH.

10. Potassium channels in myelinated nerve. Selective permeability to small cations.

1. Spontaneous firing of NG108-15 cells induced by transient exposure to ammonium chloride.

2. Hyperglycaemic hypoxia alters after-potential and fast K+ conductance of rat axons by cytoplasmic acidification.

3. Asymmetric modulation and blockade of the delayed rectifier in squid giant axons by divalent cations.

4. The effects of hyperglycaemic hypoxia on rectification in rat dorsal root axons.

5. A contribution to the history of the proton channel.