Literature DB >> 22072414

Metabolic and neurologic sequelae in a patient with long-standing anorexia nervosa who presented with septic shock and deep hypoglycemia.

Corine M de Jager1, Miriam Hoekstra, Maarten W N Nijsten, Annemieke Oude Lansink, Farouq Ismael.   

Abstract

OBJECTIVE: To report the case of a 48-year female with chronic remitting anorexia nervosa who was found comatose at home and admitted to our hospital with a deep hypoglycemia (glucose level 0.6 mmol/L; 11 mg/dL) and septic shock secondary to a bilateral pneumonia.
METHOD: Case report.
RESULTS: After admission to the critical care unit, she further displayed a number of pronounced complications known to be associated with anorexia, including hypophosphatemia, disturbed liver functions and depression of all three hematological cell lines. The neurological recovery of the patient was complicated by encephalopathy and transient tetraparesis. With initial deep hypoglycemia at presentation and persisting coma, magnetic resonance imaging performed 5 days later did not demonstrate characteristic post-hypoglycemic abnormalities. Neuroradiological examination did however reveal the presence of extensive calcifications in the basal ganglia known as Fahr's syndrome. DISCUSSION: The potential relation between anorexia nervosa and Fahr syndrome has not been described before. The fact that this patient survived a glucose level that is usually associated with a very poor outcome is probably related to its special origin.
Copyright © 2010 Wiley Periodicals, Inc.

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Year:  2010        PMID: 22072414     DOI: 10.1002/eat.20863

Source DB:  PubMed          Journal:  Int J Eat Disord        ISSN: 0276-3478            Impact factor:   4.861


  3 in total

Review 1.  Hypoglycemic encephalopathy: a case series and literature review on outcome determination.

Authors:  Jens Witsch; Hermann Neugebauer; Julia Flechsenhar; Eric Jüttler
Journal:  J Neurol       Date:  2012-04-11       Impact factor: 4.849

Review 2.  MECHANISMS IN ENDOCRINOLOGY: Anorexia nervosa and endocrinology: a clinical update.

Authors:  René Klinkby Støving
Journal:  Eur J Endocrinol       Date:  2019-01-01       Impact factor: 6.664

3.  Metabolic and nutritional needs to normalize body mass index by doubling the admission body weight in severe anorexia nervosa.

Authors:  Maria Gabriella Gentile; Chiara Lessa; Marina Cattaneo
Journal:  Clin Med Insights Case Rep       Date:  2013-04-01
  3 in total

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