| Literature DB >> 22071984 |
Mónica Ventura Ferreira1, Norina Labude, Daniela Piroth, Willi Jahnen-Dechent, Ruth Knüchel, Thomas Hieronymus, Martin Zenke, Sabine Neuss.
Abstract
The low yield of hematopoietic progenitor cells (HPC) present in cord blood grafts limits their application in clinics. A reliable strategy for ex vivo expansion of functional HPC is a present goal in regenerative medicine. Here we evaluate the capacity of several two-dimensional polymers to support HPC proliferation. Basic compatibility was tested by measuring cell viability, cytotoxicity and apoptosis of CD34(+) progenitors that were short and long-term exposed to sixteen bio and synthetic polymers. Resomer(®) RG503, PCL and Fibrin might be good alternatives to tissue culture plastic for culture of CB-derived CD34(+) progenitors. Further, these polymers will be produced in three-dimensional structures and tested for their cytocompatibility.Entities:
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Year: 2011 PMID： 22071984 DOI： 10.1007/s10856-011-4483-4
Source DB: PubMed Journal: J Mater Sci Mater Med ISSN： 0957-4530 Impact factor: 3.896