| Literature DB >> 22071254 |
Hélio A Stefani1, Giancarlo V Botteselle, Julio Zukerman-Schpector, Ignez Caracelli, Denis da Silva Corrêa, Sandra H P Farsky, Isabel D Machado, José R Santin, Cristina B Hebeda.
Abstract
A series of 2,5-diaryl substituted furans functionalized with several amino acids were synthesized and evaluated as the cyclooxygenases COX-1 and COX-2 enzymes inhibitors. The proline-substituted compound inhibited PGE(2) secretion by LPS-stimulated neutrophils, suggesting selectivity for COX-2. Molecular docking studies in the binding site of COX-2 were performed.Entities:
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Year: 2011 PMID： 22071254 DOI： 10.1016/j.ejmech.2011.10.018
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514