OBJECTIVE: The objective of the study was to evaluate whether ratios considering omphalocele diameter relative to fetal biometric measurements perform better than giant omphalocele designation at predicting inability to achieve neonatal primary surgical closure. STUDY DESIGN: Cases of fetal omphalocele that underwent evaluation between May 2003 and July 2010 were identified. Inclusion was restricted to live births with plan for postnatal repair. Omphalocele diameter upon antenatal ultrasound was compared with abdominal circumference, femur length, and head circumference, yielding the respective omphalocele (O)/abdominal circumference (AC), O/femur length (FL), and O/head circumference (HC) ratios. The absolute measurements were used to classify giant lesions. Omphalocele ratios and giant omphalocele designations were evaluated as predictors of inability to achieve primary repair. RESULTS: Among 25 included cases, staged or delayed closure occurred in 52%. With an optimal cutoff of 0.21 or greater, O/HC best predicted the primary outcome (sensitivity, 84.6%; specificity, 58.3%; odds ratio, 7.7). The O/HC of 0.21 or greater outperformed giant designations. CONCLUSION: The O/HC of 0.21 or greater best predicted staged or delayed omphalocele closure. Giant omphalocele designation, regardless of definition, poorly predicted outcome.
OBJECTIVE: The objective of the study was to evaluate whether ratios considering omphalocele diameter relative to fetal biometric measurements perform better than giant omphalocele designation at predicting inability to achieve neonatal primary surgical closure. STUDY DESIGN: Cases of fetal omphalocele that underwent evaluation between May 2003 and July 2010 were identified. Inclusion was restricted to live births with plan for postnatal repair. Omphalocele diameter upon antenatal ultrasound was compared with abdominal circumference, femur length, and head circumference, yielding the respective omphalocele (O)/abdominal circumference (AC), O/femur length (FL), and O/head circumference (HC) ratios. The absolute measurements were used to classify giant lesions. Omphalocele ratios and giant omphalocele designations were evaluated as predictors of inability to achieve primary repair. RESULTS: Among 25 included cases, staged or delayed closure occurred in 52%. With an optimal cutoff of 0.21 or greater, O/HC best predicted the primary outcome (sensitivity, 84.6%; specificity, 58.3%; odds ratio, 7.7). The O/HC of 0.21 or greater outperformed giant designations. CONCLUSION: The O/HC of 0.21 or greater best predicted staged or delayed omphalocele closure. Giant omphalocele designation, regardless of definition, poorly predicted outcome.
Authors: Teresa Victoria; Savvas Andronikou; Diana Bowen; Pablo Laje; Dana A Weiss; Ann M Johnson; William H Peranteau; Douglas A Canning; N Scott Adzick Journal: Pediatr Radiol Date: 2018-03-17
Authors: Maciej Nowacki; Arkadiusz Jundziłł; Łukasz Nazarewski; Andrzej Kotela; Tomasz Kloskowski; Joanna Skopińska-Wisniewska; Magdalena Bodnar; Aleksander Łukasiewicz; Sławomir Nazarewski; Ireneusz Kotela; Marek Kucharzewski; Marta Pokrywczyńska; Andrzej Marszałek; Tomasz Drewa Journal: Biomed Res Int Date: 2015-02-05 Impact factor: 3.411
Authors: Nina C J Peters; Annelieke Hijkoop; Rosan L Lechner; Alex J Eggink; Joost van Rosmalen; Dick Tibboel; René M H Wijnen; Hanneke IJsselstijn; Titia E Cohen-Overbeek Journal: Prenat Diagn Date: 2019-08-29 Impact factor: 3.050