Literature DB >> 2206996

Interleukin 5 activity in sera from patients with eosinophilia.

H Enokihara1, H Kajitani, S Nagashima, S Tsunogake, N Takano, K Saito, S Furusawa, H Shishido, Y Hitoshi, K Takatsu.   

Abstract

Sera from 10 patients with eosinophilia contained eosinophil colony stimulating factor (Eo-CSF) activity. Using anti murine (m) interleukin-5 (IL-5) antibody, we demonstrated that this activity was mainly derived from IL-5. Administration of prednisolone to patients decreased both Eo-CSF activity in sera and the number of eosinophils in blood. These results extend our recent study demonstrating that T cells from eosinophilic patients produce IL-5 with IL-2 stimulation and may support the speculation that IL-5 is an important factor which induces eosinophilia.

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Year:  1990        PMID： 2206996     DOI： 10.1111/j.1365-2141.1990.tb07782.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  3 in total

1.  Eosinophil hematopoietins antagonize the programmed cell death of eosinophils. Cytokine and glucocorticoid effects on eosinophils maintained by endothelial cell-conditioned medium.

Authors:  E Her; J Frazer; K F Austen; W F Owen
Journal:  J Clin Invest       Date:  1991-12       Impact factor: 14.808

Review 2.  Deposits of eosinophil granule proteins in eosinophilic cholecystitis and eosinophilic colitis associated with hypereosinophilic syndrome.

Authors:  K Tajima; T Katagiri
Journal:  Dig Dis Sci       Date:  1996-02       Impact factor: 3.199

3.  1,1'-Ethylidenebis(tryptophan) (Peak E) induces functional activation of human eosinophils and interleukin 5 production from T lymphocytes: association of eosinophilia-myalgia syndrome with a L-tryptophan contaminant.

Authors:  K A Yamaoka; N Miyasaka; G Inuo; I Saito; J P Kolb; K Fujita; S Kashiwazaki
Journal:  J Clin Immunol       Date:  1994-01       Impact factor: 8.317
  3 in total

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