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Literature DB >> 22069192

ID4 regulates mammary gland development by suppressing p38MAPK activity.

Jie Dong¹, Shixia Huang, Marian Caikovski, Shaoquan Ji, Amanda McGrath, Myra G Custorio, Chad J Creighton, Paul Maliakkal, Ekaterina Bogoslovskaia, Zhijun Du, Xiaomei Zhang, Michael T Lewis, Fred Sablitzky, Cathrin Brisken, Yi Li.

Abstract

The ID family of helix-loop-helix proteins regulates cell proliferation and differentiation in many different developmental pathways, but the functions of ID4 in mammary development are unknown. We report that mouse Id4 is expressed in cap cells, basal cells and in a subset of luminal epithelial cells, and that its targeted deletion impairs ductal expansion and branching morphogenesis as well as cell proliferation induced by estrogen and/or progesterone. We discover that p38MAPK is activated in Id4-null mammary cells. p38MAPK is also activated following siRNA-mediated Id4 knockdown in transformed mammary cells. This p38MAPK activation is required for the reduced proliferation and increased apoptosis in Id4-ablated mammary glands. Therefore, ID4 promotes mammary gland development by suppressing p38MAPK activity.

Entities: Gene Species

Mesh：

Substances：

Year: 2011 PMID： 22069192 PMCID： PMC3210500 DOI： 10.1242/dev.069203

Source DB: PubMed Journal: Development ISSN： 0950-1991 Impact factor: 6.868

42 in total

1. The Id4 HLH protein and the timing of oligodendrocyte differentiation.

Authors: T Kondo; M Raff
Journal: EMBO J Date: 2000-05-02 Impact factor: 11.598

2. Lactation defect in mice lacking the helix-loop-helix inhibitor Id2.

Authors: S Mori; S I Nishikawa; Y Yokota
Journal: EMBO J Date: 2000-11-01 Impact factor: 11.598

3. Id-1, ITF-2, and Id-2 comprise a network of helix-loop-helix proteins that regulate mammary epithelial cell proliferation, differentiation, and apoptosis.

Authors: S Parrinello; C Q Lin; K Murata; Y Itahana; J Singh; A Krtolica; J Campisi; P Y Desprez
Journal: J Biol Chem Date: 2001-08-09 Impact factor: 5.157

4. Osmotic stress regulates the stability of cyclin D1 in a p38SAPK2-dependent manner.

Authors: O Casanovas; F Miró; J M Estanyol; E Itarte; N Agell; O Bachs
Journal: J Biol Chem Date: 2000-11-10 Impact factor: 5.157

5. BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms.

Authors: Arnaud A Mailleux; Michael Overholtzer; Tobias Schmelzle; Philippe Bouillet; Andreas Strasser; Joan S Brugge
Journal: Dev Cell Date: 2007-02 Impact factor: 12.270

6. p38α Signaling Induces Anoikis and Lumen Formation During Mammary Morphogenesis.

Authors: Huei-Chi Wen; Alvaro Avivar-Valderas; Maria Soledad Sosa; Nomeda Girnius; Eduardo F Farias; Roger J Davis; Julio A Aguirre-Ghiso
Journal: Sci Signal Date: 2011-05-24 Impact factor: 8.192

7. SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia.

Authors: F C Barone; E A Irving; A M Ray; J C Lee; S Kassis; S Kumar; A M Badger; R F White; M J McVey; J J Legos; J A Erhardt; A H Nelson; E H Ohlstein; A J Hunter; K Ward; B R Smith; J L Adams; A A Parsons
Journal: J Pharmacol Exp Ther Date: 2001-02 Impact factor: 4.030

8. Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach.

Authors: C Beger; L N Pierce; M Kruger; E G Marcusson; J M Robbins; P Welcsh; P J Welch; K Welte; M C King; J R Barber; F Wong-Staal
Journal: Proc Natl Acad Sci U S A Date: 2001-01-02 Impact factor: 11.205

9. Induction of mammary gland development in estrogen receptor-alpha knockout mice.

Authors: W P Bocchinfuso; J K Lindzey; S C Hewitt; J A Clark; P H Myers; R Cooper; K S Korach
Journal: Endocrinology Date: 2000-08 Impact factor: 4.736

10. The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation.

Authors: Geum-Yi Kim; Stephen E Mercer; Daina Z Ewton; Zhongfa Yan; Kideok Jin; Eileen Friedman
Journal: J Biol Chem Date: 2002-06-10 Impact factor: 5.157

20 in total

1. Research resource: progesterone receptor targetome underlying mammary gland branching morphogenesis.

Authors: Ashlee R Lain; Chad J Creighton; Orla M Conneely
Journal: Mol Endocrinol Date: 2013-08-26

Review 2. Stress signaling and the shaping of the mammary tissue in development and cancer.

Authors: A Avivar-Valderas; H C Wen; J A Aguirre-Ghiso
Journal: Oncogene Date: 2014-01-13 Impact factor: 9.867

3. Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation.

Authors: Khanh Pham; Jie Dong; Xiqian Jiang; Ying Qu; Han Yu; Yisheng Yang; Walter Olea; Juan C Marini; Lawrence Chan; Jin Wang; Xander H T Wehrens; Xiaojiang Cui; Yi Li; Darryl L Hadsell; Ninghui Cheng
Journal: Am J Physiol Endocrinol Metab Date: 2016-11-15 Impact factor: 4.310

ID4 regulates mammary gland development by suppressing p38MAPK activity.

1. The Id4 HLH protein and the timing of oligodendrocyte differentiation.

2. Lactation defect in mice lacking the helix-loop-helix inhibitor Id2.

3. Id-1, ITF-2, and Id-2 comprise a network of helix-loop-helix proteins that regulate mammary epithelial cell proliferation, differentiation, and apoptosis.

4. Osmotic stress regulates the stability of cyclin D1 in a p38SAPK2-dependent manner.

5. BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms.

6. p38α Signaling Induces Anoikis and Lumen Formation During Mammary Morphogenesis.

7. SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia.

8. Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach.

9. Induction of mammary gland development in estrogen receptor-alpha knockout mice.

10. The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation.

1. Research resource: progesterone receptor targetome underlying mammary gland branching morphogenesis.

Review 2. Stress signaling and the shaping of the mammary tissue in development and cancer.

3. Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation.

Review 4. The biology of progesterone receptor in the normal mammary gland and in breast cancer.

5. Salvador-Warts-Hippo pathway in a developmental checkpoint monitoring helix-loop-helix proteins.

Review 6. Inhibitor of differentiation 4 (ID4): From development to cancer.

7. MicroRNA expression analysis of mammospheres cultured from human breast cancers.

Review 8. Progesterone signalling in breast cancer: a neglected hormone coming into the limelight.

9. KAT5 silencing induces apoptosis of GBC-SD cells through p38MAPK-mediated upregulation of cleaved Casp9.

Review 10. E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and Disease.