Literature DB >> 22068633

Cell signalling: mTOR targets its own inhibitor.

Katharine H Wrighton.   

Abstract

Entities:  

Year:  2011        PMID： 22068633     DOI： 10.1038/nrm3229

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


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  4 in total

1.  mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.

Authors:  Daming Gao; Hiroyuki Inuzuka; Meng-Kwang Marcus Tan; Hidefumi Fukushima; Jason W Locasale; Pengda Liu; Lixin Wan; Bo Zhai; Y Rebecca Chin; Shavali Shaik; Costas A Lyssiotis; Steven P Gygi; Alex Toker; Lewis C Cantley; John M Asara; J Wade Harper; Wenyi Wei
Journal:  Mol Cell       Date:  2011-10-21       Impact factor: 17.970

2.  mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR.

Authors:  Shanshan Duan; Jeffrey R Skaar; Shafi Kuchay; Alfredo Toschi; Naama Kanarek; Yinon Ben-Neriah; Michele Pagano
Journal:  Mol Cell       Date:  2011-10-21       Impact factor: 17.970

3.  DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy.

Authors:  Yongchao Zhao; Xiufang Xiong; Yi Sun
Journal:  Mol Cell       Date:  2011-10-21       Impact factor: 17.970

Review 4.  mTOR: from growth signal integration to cancer, diabetes and ageing.

Authors:  Roberto Zoncu; Alejo Efeyan; David M Sabatini
Journal:  Nat Rev Mol Cell Biol       Date:  2010-12-15       Impact factor: 94.444
  4 in total
  2 in total

Review 1.  Targeting the mTOR-DEPTOR pathway by CRL E3 ubiquitin ligases: therapeutic application.

Authors:  Yongchao Zhao; Yi Sun
Journal:  Neoplasia       Date:  2012-05       Impact factor: 5.715

Review 2.  Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase.

Authors:  Yi Sun; Hua Li
Journal:  Protein Cell       Date:  2012-11-08       Impact factor: 14.870
  2 in total

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